Table 3 Detailed list of analyzed studies dealing with regenerative periodontal therapy, i.e. GTR [17]

Yukna et al. 1985

n.r.

n.r.

n.r.

n.r.

yes

at 10, 20 and 30 days and 3, 6, 9 and 12 months

2

Cortellini et al. 1995a

CHX

0.2 %

2x/d

3 weeks

B

yes

1,2,3,4,5,6 (and after membran removal 1,2,3,4)

2

Mora & Ouhayoun 1995

CHX

0.2 %

n.r.

10 days

A

yes

every 10 days for the 1st month, 2x a month for months 2 and 3 and then every 3 months for 9 months

2

Cortellini et al. 1996

CHX

0.2 %

2x/d

3 weeks in the MWF group

2 months bioresorbable gr

6 weeks in the ePTFE gr

yes

1,2,3,4,5,6, then every month for 12 months

2

Tonetti et al. 1996

CHX

0.2 %

2x/d

3 weeks

B

yes

weekly for 6 weeks. After membran removal weekly for 4 weeks, then monthly up to 12 months

2

Mora et al. 1996

CHX

0.2 %

2x/d

4 weeks

B

yes

weekly 4 weeks, professional maintenance regimen after membran removal until 12 month

2

Zamet et al. 1997

CHX

0.2 %

2x/d

4 weeks

B

yes

1,2,3,4, then every 4 weeks up to 3 months and then every 3 months up to 1 yr

2

Heijl et al. 1997

CHX

0.2 %

n.r.

4–6 weeks

C

n.r.

n.r.

Mayfield et al. 1998

CHX

0.2 %

2x/d

6 weeks (test) 3 w (controlgr.)

B

yes

weekly for 4 weeks, then monthly until 6 month, then every 4–6 weeks up to 1 yr

2

Okuda et al. 2000

CHX

0.12 %

3x/day

6 weeks

C

yes

weekly for 6 weeks, then monthly up to 12 months

2

Zybutz et al. 2000

CHX

0.12 %

2x/d

8 weeks

C

yes

2,4,6,8,12 weeks

2

Ratka-Kruger et al. 2000

CHX

0.2 %

3x/day

6 weeks

C

yes

at 3, 6 and 12 months

1

Sculean et al. 2001

CHX

0.2 %

2x/d

6 weeks

C

yes

every 2nd week for 2 months, then monthly up to 12 months

2

Zucchelli et al. 2002

CHX

0.12 %

2x/d

11 weeks

C

yes

Weekly for 11 weeks, then monthly up to 1 yr

2

Tonetti et al. 2002

CHX

0.12 %

2x/d

4 weeks

B

yes

at weeks 1, 2, 3, 4, 6. Then 3,6,9 month recall

2

Wachtel et al. 2003

CHX

0.2 %

2x/d

4 weeks

B

n.r.

n.r.

Sculean et al. 2003

CHX

0.2 %

2x/d

4 weeks

B

yes

every 2nd week for 2 months,then monthly up to 12 months

2

Sculean et al. 2004

CHX

0.2 %

2x/d

6 weeks

C

yes

every 2nd week for 2 months,then monthly for the 1st yr, after 1st yr for 5 yrs every 3 months

2

Tonetti et al. 2004

CHX

0.12 %

2x/d

4 weeks

B

yes

at weeks 1, 2, 3, 4, 6 and 8. Then at 3, 6 and 9 months

2

Vouros et al. 2004

CHX

0.12 %

2x/d

4 weeks

B

yes

monthly up to 12 months

1

Francetti et al. 2004

CHX

0.12 %

2x/d

6 weeks

C

yes

recall monthly during 1 yr, then at 18 and 24 month

1

Francetti et al. 2005

CHX

0.12 %

2x/d

6 weeks

C

n.r.

n.r.

Aimetti et al. 2005

CHX

0.2 %

2x/d

3 weeks

B

yes

1,2,3,4, then every month for 12 months

2

Sculean et al. 2005

CHX

0.2 %

2x/d

4 weeks

B

yes

every 2nd week for 2 months,then monthly up to 12 months

2

Sculean et al. 2007

CHX

0.2 %

2x/d

4 weeks

B

yes

every 2nd week for 2 months,then monthly up to 12 months

after 1st yr for 5 yrs every 3 months

2

Sculean et al. 2008

CHX

0.2 %

2x/d

6 weeks

C

yes

every 2nd week for 2 months,then once per month for 1 yr, then every 3 months for 10 yrs

2

Kasaj et al. 2008

CHX

0.2 %

2x/d

4 weeks

B

yes

every 2 week for 2 months, after every 4 weeks

2

Fickl et al. 2009

n.r.

n.r.

Stein et al. 2009

CHX

0.2 %

2x/d

4 weeks

B

yes

every 2nd week for 2 months,then monthly up to 12 months

2

Cortellini et al. 2011

CHX

0.12 %

2x/d

4 weeks

C

yes

1,2,3,4,5,6, then 3 month recall for 1 yr

2