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Table 4 Crude and Adjusted Ratio of mean levels of inflammatory mediators in women with overall periodontal disease and women with moderate or severe periodontal disease compared with women without periodontal disease

From: Salivary and serum inflammatory mediators among pre-conception women with periodontal disease

Inflammatory mediator

Women with overall periodontal disease versus without periodontal disease (mean ± SD) N = 533

Women with moderate/severe periodontal disease versus without periodontal disease (mean ± SD) N = 338

Crude ratio

Adjusted ratioa

P

Crude ratio

Adjusted ratioa

P

Saliva

 IL-1β (pg/ml)

1.23

1.23

<0.001

1.26

1.25

<0.001

 β-glucuronidase (U/L)

1.09

1.10

<0.001

1.13

1.13

<0.001

 TNF-α (pg/ml)

1.36

1.36

<0.001

1.39

1.40

<0.001

 IL-6 (pg/ml)

1.21

1.21

<0.001

1.25

1.25

<0.001

Serum

 IL-1β (pg/ml)

1.49

1.49

<0.001

1.48

1.50

0.001

 β-glucuronidase (U/L)

1.13

1.12

0.048

1.15

1.15

0.025

 TNF-α (pg/ml)

1.54

1.53

<0.001

1.62

1.62

<0.001

 IL-6 (pg/ml)

1.17

1.18

0.039

1.16

1.17

0.077

  1. P values are for adjusted ratios only
  2. aMultivariable linear regression adjusted for women’s age, smoking, educational level, employment status, monthly family income, parity, family periodontal disease history, oral health insurance, BMI, stress score, oral hygiene