Table 2 Study charicteristics

Ay, Z. Y. 2012

Cross-sectional

Turkey (Caucasion)

CP/AP

21/20

47/37/33

28/27.6/24.39

Free

Free

Leptin

●●●○●●●○○○○(6/12)

Ay, Z. Y 2013

Cross-sectional

Turkey (Caucasion)

AP

6/6

38.67/32.33

25.78/23.20

Free

Free

Leptin

●●●○●●●●○○○(7/12)

Cecilia C Z 2015

Cross-sectional

Sweden (Caucasion)

P

14/61

14.5/14.5

35.9/37.4

Not mentioned

Mixed

Leptin/Adiponectin

●●●○●●●●○○○(7/12)

Davies, R. C. 2011

Cross-sectional

UK (Caucasion)

AP

30/30

36.7/36.3

26.0/25.3

Free

Mixed

Leptin/Adiponectin

●●○○●●●●○○○(6/12)

Furugen, R 2008

Cross-sectional

Japan(Asian)

CP

84/70

76/76

22.77/22.39

Not mentioned

Mixed

Adiponectin

●●●○●●●●○○○(7/12)

Gangadhar, V.2011

Cross-sectional

India(Indian)

P

25/25

18-60

Not mentioned

Not mentioned

Mixed

Leptin

●●○○●○●○○○○(4/12)

Gundala, R.2014

Cross-sectional

India(Indian)

CP

30/30;30/30

44.9/48.3;48.9/47.8

27.4/21.7;30.8/21.6

Free/AMI

Mixed

Leptin

●●●○●●●○○○○(6/12)

Karthikeyan, B. V 2007

Cross-sectional

India(Indian)

CP

14/14

30–39 matiched

Normal BMI

Not mentioned

Mixed

Leptin

●●○●●●●●○○○(7/12)

Mendoza-Azpur 2015

Cross-sectional

Peru (Peruvian)

CP

19/29;24/21

41.4/42.5;47.2/26.9

Normal BMI; Obesity

Free

Free

Leptin/Adiponectin

●●●○●●●●○○○(7/12)

Nagano, Y 2011

Cross-sectional

Japan(Asian)

CP

62/89

55.7/50.7

24.4/24.2

Not mentioned

Mixed

Adiponectin

●●○●●○●●○○○(6/12)

Purwar, P.A 2015

Cross-sectional

India(Indian)

CP

44/40

49.3/49.9

20.62/20.69

Free

Free

Leptin

●●●○●●●●○○○(7/12)

Saito, T 2008

Cross-sectional

Japan(Asian)

CP

34/42

55.2/55.1

23.3/21.9

Not mentioned

Mixed

Adiponectin

●●●●●●●○○○○(7/12)

Sete, M. R.

Cross-sectional

Brazil (Brazilian)

CP

15/15

45.7/32.1

28.8/Not mentioned

Free

Free

Leptin/Adiponectin

●●○○●●●○○○○(5/12)

Shi, D 2015

Cross-sectional

China (Asian)

AP

90/44

26.2/25.6

21.9/21.1

Free

Mixed

Leptin

●●●○●●●●○○○(7/12)

Thanakun, S.2014

Cross-sectional

Thai (Asian)

CP

58/67

50.0/46.0

24.9/23.5

Mixed

Mixed

Leptin/Adiponectin

●●●○●●●●○○○(7/12)

Zimmermann, G. S2013

Cross-sectional

Brazil (Brazilian)

CP

20/20;20/18

47.8/42.9;51.2/43.2

23.0/23.4;33.2/33.9

Free

Free

Leptin/Adiponectin

●●●○●●●●○○○(7/12)

Authors and years

Study design

Country (Ethnicity)

Group size

Age(NG/OBG)

BMI(NG/OBG

Systemic disease

Smoking

Adipokine

Periodontal treatment

Quality assessment

Time interval

Altay, U. A 2013

Double-arm clinical trial

Turkey (Caucasion)

24/22

42.5/45.6

26.3/32.2

Free

Mixed

Leptin

SRP

●◐●●◐●◐●(13/16)

3 month

Behle, Jan H 2009

Single-arm clinical trial

USA (mixed)

28

43.3

Not mentioned

Free

Free

Adiponectin

SRP + Periodontal surgery

●◐●●◐◐●◐ (12/16)

1 month

Bharti, P 2013

Controlled clinical trial

Japan(Asian)

21

60.2

24.2

T2DM

Free

Adiponectin

SRP + Topical antibiotics

●◐●●◐●◐◐(12/16)

2 month

Duzagac, E 2015

Double-arm clinical trial

Turkey (Caucasion)

15/15

41.06/40.66

22.14/36.26

Free

Free

Adiponectin

SRP

●◐●●◐●●◐ (13/16)

3 month

Goncalves, T. E A 2015

Double-arm clinical trial

Brazil (mixed)

24/24

48.4/48.8

24.4/33.2

Free

Free

Leptin/Adiponectin

SRP

●●●●◐●◐●(14/16)

3 month

Goncalves, T. E B 2015

Double-arm clinical trial

Brazil (mixed)

20/20

48.5/50.0

23.4/36.1

Free

Free

Leptin/Adiponectin

SRP

●●●●◐●●●(15/16)

3 month

Purwar, P.B 2015

Single-arm clinical trial

India(Indian)

22

35-60

20.45

Free

Free

Leptin

SRP

●◐●●◐●◐●(13/16)

3 month

Shimada, Y.2010

Single-arm clinical trial

Japan(Asian)

33

55.1

22.5

Free

Mixed

Leptin

SRP

●◐●●◐◐●◐(12/16)

1 month

Sun, W. L2011

Randomized controlled clinical trial

China(Asian)

82

55.13

23.71

T2DM

Free

Adiponectin

SRP + Periodontal surgery

●◐●●◐●●◐ (13/16)

3 month