Novel caries loci in children and adults implicated by genome-wide analysis of families

BMC Oral Health

Table 4 Linkage peaks in highest LOD score regions

Chr	Trait	Peak^a			Support Interval (Mb)^b for Peak with LOD ≥ 2		Closest Genes within Support Interval^c
Chr	Trait	SNP	bp	LOD	Left	Right
1	QTOT1	rs12096999	178,046,412	1.19			CACNA1E; LAMC2
1	PRIM	rs1281317	180,232,077	2.90	174.78	182.03	CACNA1E; LAMC2
2	QTOT2	rs7572396	59,893,993	2.30	58.63	64.29	BCL11A ^d
2	QTOT1	rs13420242	71,117,276	1.55			ALMS1; STAMBP
2	QTOT2	rs831535	73,976,537	2.10	65.23	79.72	ALMS1; STAMBP
3	PRIM	rs9842115	20,378,197	2.50	15.06	22.19	KAT2B ^d
3	QTOT1	rs2044594	74,474,447	2.12	67.65	76.08	GXYLT2
5	QTOT1	rs11748635	123,232,224	1.24			SLC12A2; MEGF10; IL gene family
5	QTOT2	rs6866597	128,905,516	2.76	122.43	133.84	SLC12A2; MEGF10; IL gene family
6	QTOT1	rs240642	158,117,314	2.38	156.81	159.48	TMEM181; ARID1B
6	QTOT2	rs9295289	158,387,494	1.96			TMEM181; ARID1B
19	QTOT1	rs11084325	59,424,868	1.12			NLRP2; NLRP7; NLRP, KIR, and LILR gene families
19	QTOT2	rs1671133	60,198,861	2.15	59.42	61.47	NLRP2; NLRP7; NLRP, KIR, and LILR gene families

Note: ^aNovel regions with LOD ≥ 2.00, and secondary peaks ≥1.0 observed for the other phenotypes; peak LOD ≥ 2.00 shown in bold
^bSupport interval for LOD ≥ 2.00; Mb: 10⁶ (or 1 million) bp
^cGenes with a potential role in caries incidence. If no such gene is identified, then the closest gene to the peak reported
^dUnknown role in caries incidence; closest gene to the linkage peak SNP

ISSN: 1472-6831