Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview

Heidari, Zahra; Moudi, Bita; Mahmoudzadeh-Sagheb, Hamidreza

doi:10.1186/s12903-019-0715-7

BMC Oral Health

Table 1 Cytokine gene polymorphisms and association with chronic periodontitis

From: Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview

Cytokine gens	SNP analyzed	Associated with periodontitis –/+	Year	Country	Publication
IL-1α	– 889	–	2013	Macedonia	[24]
	– 889, + 4854	–	2015	India	[25]
	– 889	–	2015	Algeria	[31]
	– 889	+	2000	England	[169]
	– 889	–	2003	Thailand	[39]
	+ 4845	–	1999	America	[37]
	+ 4845	–	2007	Japan	[38]
	– 889, + 4845	+	2012	America	[27]
	– 889	+	2013	China	[28]
	– 889	+	2016	China	[29]
	– 889	+	1997	America	[170]
	– 889	+	2007	Brazil	[41]
	– 889	+	2001	Netherlands	[42]
	– 889	+	2007	Germany	[43]
	– 889	–	2005	America	[47]
	– 889	–	1998	America	[50]
	– 889	–	2002	Australia	[51]
	– 889	+	2008	Germany	[52]
	+ 4854	–	2008	Denmark	[57]
	– 889	+	2005	England	[58]
	+ 4845	–	2000	China	[61]
	+ 4845	+	2000	America	[62]
	+ 4845	+	2005	India	[63]
	+ 4845	+	2000	America	[65]
	– 889	–	2007	Finland	[75]
	+ 4845 – 889	– +	2008	Greece	[81]
	+ 4845	–	2006	Greece	[121]
	+ 4845	–	2009	Japan	[130]
	– 889	+	2012	China	[148]
IL-1β	– 511 + 3962	+ –	2013	Macedonia	[24]
	– 511 + 3954	- +	2015	India	[25]
	– 511	–	2015	China	[30]
	– 511 + 3954	– +	1997	America	[170]
	+ 3954	+	2015	Algeria	[31]
	+ 3954	+	2007	Japan	[38]
	+ 3954	–	2003	Thailand	[39]
	+ 3954	+	1999	America	[37]
	+ 3954	+	2012	America	[27]
	+ 3954	+	2016	China	[29]
	+ 3954	+	2001	Netherlands	[42]
	+3954	+	2007	Germany	[43]
	–511, – 1464, – 3737, + 3877	+	2015	America	[44]
	+ 3954	+	2015	China	[45]
	+3954	+	2005	America	[47]
	+3954	+	2005	Brazil	[48]
	+3954 – 511	+ –	1998	America	[50]
	+3954	+	2002	Australia	[51]
	+3954	+	2008	Germany	[52]
	+3954	–	2016	Colombia	[53]
	+3954	–	2015	Brazil	[54]
	+3954, − 511 − 31	+ –	2015	India	[55]
	+ 3954	+	2012	India	[56]
	+3954, – 511	+	2008	Denmark	[57]
	– 511, + 3954	–	2005	England	[58]
	+3954	–	2000	China	[61]
	+3954	+	2000	America	[62]
	+3954	+	2005	India	[63]
	+3954	+	2000	America	[65]
	+3954	–	2007	Finland	[75]
	+3954 – 511	+ –	2008	Greece	[81]
	+3954	–	2006	Greece	[121]
	+3954 –31	+ –	2009	Japan	[130]
IL1RN	IL1R pstl1970, IL1RN mspa111100	–	2013	Macedonia	[24]
	IL1RN VNTR	–	2015	India	[25]
	IL1RN + 2018	–	2007	Japan	[38]
	IL1RN VNTR	+	2001	Netherlands	[42]
	IL1RN VNTR	–	2008	Denmark	[57]
	IL1RN VNTR	+	2012	China	[59]
	IL1RN VNTR	+	2006	Turkey	[60]
	+ 2018	–	2009	Japan	[130]
IL-6	–174	+	2005	England	[58]
	–174	–	2010	Turkey	[68]
	–174	+	2007	Brazil	[41]
	–174	+	2003	Brazil	[72]
	–174	+	2014	Brazil	[73]
	–174	+	2006	Germany	[74]
	–174	+	2007	Finland	[75]
	–373 –597, –572, –190, – 174	+ –	2005	Japan	[76]
	– 174	–	2009	England	[78]
	– 572 – 597, – 174	+ –	2004	Czech	[79]
	–1363 – 572	+ –	2014	China	[80]
	–174	–	2008	Greece	[81]
	–572, – 174	–	2009	Japan	[130]
	–174 + 874	+ –	2006	Germany	[74]
IL-10	– 627, – 1082	–	2005	England	[58]
	– 1082, – 819, – 592	–	2010	Turkey	[68]
	– 1082	–	2006	Germany	[74]
	– 1082	–	2007	Finland	[75]
	– 1082	+	2003	Sweden	[90]
	– 819, – 592 – 1087	+ –	2004	Brazil	[91]
	– 592 – 819	+ –	2007	Turkey	[92]
	– 1082 – 819, – 592	+ –	2012	Macedonia	[93]
	– 819, – 592 – 1082	+ –	2012	China	[94]
	– 819, – 592 – 1082	+ –	2012	Portugal	[171]
	– 1082	+	2015	India	[96]
	– 1082, – 592	+	2012	Germany	[97]
	– 1082	–	2015	Brazil	[98]
	– 1082	–	2014	Brazil	[99]
	– 592	+	2008	Brazil	[102]
	– 1082, – 819, – 592	–	2008	Germany	[145]
	– 1082, – 819, – 592	–	2001	Japan	[106]
	– 1082	–	2006	Germany	[74]
	– 1082, – 819	–	2009	Japan	[130]
TGF-β	– 509, – 788	–	2013	Iran	[10]
	– 29	+	2013	Iran	[10]
	Codons 10 and 25	–	2010	Turkey	[68]
	Codon 10 Codon 25	– +	2006	Germany	[74]
	– 988, – 800, – 509, Codons 10 and 25	–	2002	Czech	[129]
	– 509, + 869, + 915	–	2009	Japan	[130]
	+ 915 Thr263Ile and 713/8delC	+ –	2006	Turkey	[131]
	− 509	+	2009	China	[133]
	Codons 10 and 25	+	2009	Macedonia	[134]
	Codon 25 Codon 10	+ –	2006	Germany	[74]
IFN-γ	+ 874	+	2015	Iran	[8]
	+ 874	–	2010	Turkey	[68]
	+874	–	2006	Germany	[74]
	+874	+	2008	Germany	[145]
	– 5644	–	2008	Iran	[146]
	+874	–	2011	Czech	[147]
IFN-γR1	– 611, + 189, + 95	–	2015	Iran	[8]
TNF-α	– 308	–	1997	America	[170]
	– 1031, – 863, – 857	+	2003	Japan	[46]
	– 308	+	1999	America	[48]
	– 308	–	2005	England	[58]
	– 308	+	2010	Turkey	[68]
	– 308	–	2006	Germany	[74]
	– 308	–	2007	Finland	[75]
	– 308	–	2008	Greece	[81]
	– 308	–	2014	Iran	[108]
	– 308	–	2003	Czech	[111]
	– 1031 – 857, – 308, – 238	+ –	2013	China	[114]
	– 308, – 863 – 238	+ –	2014	China	[115]
	– 308	+	2015	Turkey	[116]
	– 308, – 238	+	2008	Germany	[117]
	– 308	–	2005	Sweden	[118]
	– 308	–	2004	Germany	[119]
	– 238, – 308, + 252	–	1998	America	[120]
	– 308	–	2006	Greece	[121]
	– 863, – 857	–	2009	Japan	[130]
	– 308	–	2006	Germany	[74]
Vitamin D Receptor	– 1056	+	2005	England	[58]
	FokI ApaI, BsmI	+ –	2007	Japan	[160]
	TaqI, ApaI, BsmI	–	2008	Turkey	[161]
	TaqI, BsmI	+	2004	Brazil	[162]
	TaqI FokI	+ –	2003	Japan	[163]
	TaqI	–	2002	China	[164]
	TaqI	+	2013	India	[165]
	ApaI, BsmI TaqI	+ –	2013	Jordan	[166]
	ApaI BsmI, FokI	+ –	2015	Libya	[167]

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