Table 6 Treatment characteristics and early wound healing assessment
Author, year of publication | Treatment prior to intervention | Intervention | Specific EMD treatment | Specific GTR treatment | Suture (material/time remotion) | Post-surgical medication | Periodontal parameters assessed | Maintenance | Parameters for early wound healing assessment |
|---|---|---|---|---|---|---|---|---|---|
A.Sculean et al. 1999a [56] | 3 mo bs: OhI + FM supra- and subgingival Sc | lA, intracrevicular incisions, full flap, GrTr, ScRp | 2 min 24% EDTA gel, EMD | BM | NA 14 days | Amox (375 mg TID) Metro (275 mg TID) for 10 days | GI, BOP, PD, GR, CAL | 0.12% CHX (TID) first 6 w. Tooth brushing resumed. Rv each 2 w (2 mo) and once a month afterwards | Allergic reactions, suppuration, abscess formation, swelling (1w). Membrane exposure (3w) |
A.Sculean et al. 1999b [60] | 3 mo bs: OhI + FM supra- and subgingival Sc | lA, intracrevicular incisions, full flap, GrTr, ScRp | 2 min 24% EDTA gel, EMD | BM | Non-r e-PTFE sutures 14 days | Amox (1 g/d) for 1 w | PD, GR, CAL | 0.12% CHX (BID) first 6 w. Tooth brushing resumed. Rv (professional tooth cleaning) each 2 w (6 mo) | Allergic reactions, suppuration abscess formation, membrane exposure |
N. Donos et al. 2004 [62] | 3 mo bs: OhI, ScRp | lA, intracrevicular incisions, full flap, GrTr, ScRp | 2 min 24% EDTA gel, EMD (4 sites) | BM alone or BM + EMD | Non-r e-PTFE sutures 14 days | Metro (250 mg TID) for 1 w | BOP, PAL-V, PAL-H | 0.2% CHX (BID) for 1 min first 6 w. Rv each 1 w (6 w): tooth polishing and Li 0.2% CHX. Tooth brushing resumed. Supragingival tooth polishing + OhI once a mo afterwards | Allergic reaction, abscess formation, membrane exposure (first 2 w) |
P. Cortellini et al. 2005 [57] | Motivation, OhI, ScRp, Flap surgery in the remaining portions of the dentition | lA, SPPF, MPPT, crestal incision, full flap, GrTr, ScRp | EMD | e-PTFE TrM or BM or BM + BG | 5–0, 6–0 and 7–0 Non–r e-PTFE sutures 7 days | Doxycycline (100 mg BID) for 1 week. | FMPS, FMBS, BOP, PD, GR, CAL, Rx defect angle | 0.12% CHX (TID) and weekly prophylaxis for 6 w. Resumption oral hygiene:2 to 4 w after M removal or when BM were fully resorbed, after 4–5 w EMD group Rv monthly for 1 year | Primary closure recorded weekly for 6 w |
A. Crea et al. 2008 [61] | 3 mo bs: non-surgical periodontal therapy | lA, SPPF, full flap, periosteal releasing, GrTr, ScRp | 2 min 24% EDTA gel, EMD | e-PTFE M | 4–0 Non-r e-PTFE sutures 10 days | One day prior to surgery, Amox (500 mg BID) for 6 days | PD, CAL, GR, BOP, PI Is: IC, Rs-BC, CEJ-BD, CEJ-BC RMDD, RVBG | 1% CHX gel (TID) (4 w) Rv each 1 w (first 6 w). Rv every 3 mo. At each visit: supra-gingival debridement teeth polish, OhI, BOP, PI assessment | Wound dehiscence, pain or discomfort, abscess formation, swelling, allergic reactions (5–6 days) |
V. Iorio-Siciliano et al. 2011 [58] | Non-surgical mechanical debridement | lA, MPPT or SPPF,full flap, GrTr, ScRp | 2 min 24% EDTA gel, EMD | e-PTFE TrM | 5–0 Non-r sutures 7–10 days | 600 mg Ibuprofen immediately before the surgery and after 4 h | FMPS, FMBS, PD, REC, CAL, Is: IVLD: CEJ-BD, VLD: BC-BD, HLD: Rs-BC, Rx defect angle | 0.12% CHX (first 2 w) Modified oral hygiene procedures (4 w). Professional maintenance care after 2 and 4 w and after 3,6,9,12 mo | Early wound healing complications, membrane exposure after 1 w |
V. Iorio-Siciliano et al. 2014 [59] | Non-surgical mechanical debridement | lA, MPPT or SPPF, full flap, GrTr, scaling and root planing | 2 min 24% EDTA gel + DBBM particles (0.25 to 1.0 mm) + EMD | DBBM + BM | 5–0 Non-r sutures 7–10 days | 600 mg Ibuprofen immediately before surgery and after 4 h or 500 mg Acetaminophen immediately before and after 6 h | FMPS, FMBS, PD, REC, CAL, Is: CEJ-BD, VLD: BC-BD HLD: Rs-BC | 0.12% CHX (first 2 w) Modified oral hygiene procedures (4 w). Professioal maintenace care after 2 and 4 w and after 3,6,9,12 mo | Early wound healing complications, membrane exposure after 1 w |