Table 6 Loci showing significant heterogeneity between African Americans and Caucasians caries GWASs
From: Pilot GWAS of caries in African-Americans shows genetic heterogeneity
Phenotype | SNP | CHR | BP | P-value (AA) | Effect Size (AA) | SE (AA) | Effect Size (C) | SE (C) | Q Statistic P-value |
|---|---|---|---|---|---|---|---|---|---|
DMFT | rs62295581 | 4 | 11,844,859 | 2.05E-06 | 6.403 | 1.173 | − 0.6366 | 0.5008 | 3.40E-08 |
rs12171500 | 5 | 76,460,134 | 1.37E-06 | 15.92 | 2.507 | 0.1616 | 0.4686 | 6.46E-10 | |
rs4331298 | 15 | 71,918,351 | 3.01E-06 | 4.054 | 0.818 | −0.6631 | 0.3067 | 6.75E-08 | |
rs72787939 | 16 | 26,556,887 | 6.34E-07 | 4.617 | 0.8189 | −1.076 | 0.4973 | 2.81E-09 | |
DMFS | rs12171500 | 5 | 76,460,134 | 1.96E-06 | 57.37 | 7.984 | 0.8305 | 1.491 | 3.37E-12 |
rs72787939 | 16 | 26,556,887 | 2.20E-07 | 15.85 | 2.63 | −4.171 | 1.594 | 7.51E-11 | |
dft | rs11718323 | 3 | 20,915,514 | 2.37E-06 | 9.527 | 1.462 | 0.44 | 0.285 | 1.06E-09 |
rs78777602 | 3 | 24,821,055 | 1.29E-06 | 9.482 | 1.438 | −0.1403 | 0.2646 | 4.67E-11 | |
rs1568206 | 3 | 1.07E+ 08 | 9.33E-07 | 3.087 | 0.5053 | 0.04032 | 0.2202 | 3.25E-08 | |
rs1112769 | 3 | 1.88E+ 08 | 3.65E-06 | 5.947 | 0.9909 | −0.3341 | 0.2187 | 6.02E-10 | |
rs62316615 | 4 | 1.14E+ 08 | 2.68E-06 | 8.023 | 1.264 | −0.1937 | 0.2483 | 1.79E-10 | |
rs2515501 | 8 | 6,412,625 | 4.54E-06 | 6.477 | 1.051 | −0.1906 | 0.1931 | 4.39E-10 | |
rs10504504 | 8 | 72,185,924 | 3.23E-06 | 4.625 | 0.771 | −0.06708 | 0.2221 | 4.98E-09 | |
rs74949229 | 10 | 9,526,946 | 4.38E-06 | 7.142 | 1.128 | 0.2898 | 0.2229 | 2.53E-09 | |
rs79812076 | 12 | 1.03E+ 08 | 2.17E-06 | 6.012 | 0.9667 | 0.5207 | 0.2254 | 3.16E-08 | |
rs9630337 | 13 | 68,582,970 | 4.47E-06 | 6.97 | 1.107 | −0.5214 | 0.2149 | 3.07E-11 | |
dfs | rs74574927 | 3 | 24,768,865 | 2.44E-06 | 16.13 | 2.251 | −0.6646 | 0.6546 | 7.83E-13 |
rs17606253 | 6 | 1.12E+ 08 | 1.85E-06 | 12.19 | 1.928 | 0.2342 | 0.4277 | 1.41E-09 | |
rs11008779 | 10 | 32,413,987 | 3.22E-06 | 9.853 | 1.725 | −0.4776 | 0.3681 | 4.72E-09 | |
rs61950818 | 13 | 63,216,679 | 2.70E-06 | 15.35 | 2.346 | −0.01181 | 0.4964 | 1.49E-10 | |
rs9915753 | 17 | 73,011,448 | 3.60E-07 | 12.24 | 1.905 | −0.1695 | 0.348 | 1.47E-10 | |
rs74574927 | 3 | 24,768,865 | 2.44E-06 | 16.13 | 2.251 | −0.6646 | 0.6546 | 7.83E-13 |