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Table 3 Top 20 highest* and lowest* mean CLR OTU for the overall cohort and by age categories, and their linear correlation with age

From: Composition and diversity of the subgingival microbiome and its relationship with age in postmenopausal women: an epidemiologic investigation

Rank Order*

OTU Label

Culture Status

Socransky Complex

Overall Cohort (N = 1219)

Age Categories (years)

Linear Correlation

     

50–59 (N = 239)

60–69 (N = 554)

≥70 (N = 426)

p-value

Pearson r

p-value

CLR OTU

Mean (SE)

CLR OTU

Mean (SE)

CLR OTU

Mean (SE)

CLR OTU

Mean (SE)

20 Most Abundant Species

 1

Veillonella dispar

N

–

8.25 (0.06)

8.23 (0.13)

8.11 (0.09)

8.45 (0.10)

0.045

0.08

0.008

 2

Streptococcus oralis

N

Y

8.06 (0.05)

8.40 (0.11)

8.06 (0.08)

7.87 (0.09)

0.002

−0.10

<.001

 3

Veillonella parvula

N

P

7.60 (0.07)

7.48 (0.15)

7.45 (0.09)

7.86 (0.11)

0.014

0.10

0.001

 4

Fusobacterium nucleatum_subsp._vincentii

N

O

6.43 (0.08)

6.21 (0.17)

6.48 (0.11)

6.50 (0.13)

0.356

0.02

0.587

 5

Selenomonas sputigena

N

–

5.63 (0.08)

5.34 (0.17)

5.44 (0.12)

6.03 (0.14)

0.001

0.10

<.001

 6

Fusobacterium nucleatum_subsp._animalis

N

–

5.39 (0.07)

5.29 (0.14)

5.29 (0.10)

5.57 (0.12)

0.136

0.10

0.106

 7

Campylobacter gracilis

N

O

5.19 (0.05)

5.02 (0.11)

5.15 (0.07)

5.33 (0.09)

0.052

0.10

0.016

 8

Fusobacterium nucleatum_subsp._polymorphum

N

O

5.19 (0.07)

5.36 (0.15)

5.28 (0.09)

4.97 (0.12)

0.052

−0.10

0.019

 9

Prevotella oris

N

–

5.08 (0.09)

5.25 (0.18)

5.05 (0.13)

5.03 (0.16)

0.646

−0.10

0.118

 10

Streptococcus sanguinis

N

Y

4.91 (0.07)

5.57 (0.15)

5.04 (0.10)

4.38 (0.13)

<.001*

−0.18

<.001*

 11

Corynebacterium matruchotii

N

–

4.81 (0.07)

4.87 (0.17)

4.86 (0.10)

4.70 (0.12)

0.550

−0.04

0.171

 12

Selenomonas noxia

N

–

4.81 (0.08)

4.63 (0.18)

4.69 (0.11)

5.06 (0.13)

0.049

0.10

<.001

 13

Prevotella nigrescens

N

O

4.31 (0.10)

4.48 (0.21)

4.28 (0.15)

4.26 (0.18)

0.714

− 0.03

0.370

 14

Parvimonas micra

N

–

4.29 (0.08)

4.08 (0.17)

4.35 (0.11)

4.33 (0.12)

0.401

0.00

0.967

 15

Rothia dentocariosa

U

–

4.28 (0.09)

4.46 (0.19)

4.38 (0.13)

4.04 (0.15)

0.113

−0.10

0.008

 16

Fusobacterium sp._oral_taxon_203

N

–

4.23 (0.10)

4.08 (0.22)

4.36 (0.15)

4.16 (0.17)

0.497

−0.01

0.713

 17

Streptococcus gordonii

N

Y

4.19 (0.08)

3.93 (0.18)

4.15 (0.12)

4.40 (0.13)

0.090

0.04

0.039

 18

Granulicatella adiacens

N

–

4.15 (0.06)

4.23 (0.14)

4.11 (0.09)

4.15 (0.10)

0.749

0.00

0.991

 19

Streptococcus intermedius

N

Y

3.94 (0.10)

4.33 (0.21)

3.86 (0.15)

3.81 (0.16)

0.119

−0.10

0.016

 20

Actinomyces naeslundii

N

B

3.85 (0.06)

4.00 (0.14)

3.88 (0.09)

3.72 (0.11)

0.230

−0.10

0.008

20 Least Abundant Species

 1

Porphyrobacter tepidarius

N

–

− 3.58 (0.03)

−3.51 (0.08)

− 3.65 (0.05)

− 3.54 (0.06)

0.216

0.01

0.869

 2

Sphingomonas sp._oral_taxon_006

P

–

− 3.55 (0.04)

− 3.49 (0.08)

− 3.60 (0.05)

− 3.52 (0.06)

0.407

−0.00

0.989

 3

Pyramidobacter piscolens

P

–

− 3.53 (0.04)

− 3.44 (0.10)

− 3.60 (0.06)

− 3.47 (0.07)

0.251

− 0.01

0.919

 4

Leptothrix sp._oral_taxon_025

P

–

−3.50 (0.04)

− 3.37 (0.08)

− 3.53 (0.06)

−3.53 (0.06)

0.216

−0.04

0.221

 5

Treponema sp._oral_taxon_247

P

–

−3.45 (0.05)

−3.35 (0.09)

− 3.50 (0.07)

−3.44 (0.08)

0.436

− 0.02

0.566

 6

Atopobium sp._oral_taxon_416

P

–

−3.38 (0.05)

−3.45 (0.09)

− 3.44 (0.07)

−3.27 (0.09)

0.202

0.10

0.042

 7

Brevundimonas diminuta

N

–

−3.30 (0.04)

−3.17 (0.09)

− 3.35 (0.06)

−3.30 (0.07)

0.232

−0.03

0.306

 8

Prevotella multiformis

N

–

−3.08 (0.06)

−3.12 (0.11)

− 3.10 (0.09)

−3.05 (0.10)

0.901

0.03

0.359

 9

GN02_[G-2] sp._oral_taxon_873

P

–

−3.06 (0.05)

−3.08 (0.12)

− 3.03 (0.08)

−3.10 (0.09)

0.851

−0.00

0.927

 10

Streptococcus sobrinus

U

–

−3.04 (0.06)

−3.21 (0.10)

− 3.19 (0.09)

−2.75 (0.14)

0.005

0.11

<.001*

 11

Aggregatibacter actinomycetemcomitans

P

–

− 3.01 (0.07)

− 2.97 (0.15)

− 3.09 (0.10)

− 2.94 (0.11)

0.575

0.03

0.349

 12

Fretibacterium sp._oral_taxon_361

P

–

−2.98 (0.06)

−3.18 (0.10)

−2.97 (0.09)

− 2.88 (0.11)

0.207

0.02

0.469

 13

Butyrivibrio sp._oral_taxon_080

P

–

−2.96 (0.06)

−2.85 (0.13)

− 2.90 (0.09)

−3.10 (0.09)

0.193

−0.10

0.038

 14

Lactobacillus gasseri

N

–

−2.95 (0.06)

−3.08 (0.12)

−3.09 (0.09)

−2.70 (0.12)

0.012

0.10

0.002

 15

Mitsuokella sp._oral_taxon_521

N

–

−2.90 (0.06)

−2.91 (0.12)

− 2.92 (0.08)

−2.87 (0.11)

0.929

0.02

0.603

 16

Microbacterium flavescens

P

–

−2.89 (0.04)

−2.73 (0.09)

− 2.89 (0.06)

−2.97 (0.07)

0.151

−0.10

0.051

 17

Prevotella sp._oral_taxon_475

N

–

−2.87 (0.06)

−2.81 (0.12)

− 2.84 (0.09)

−2.95 (0.09)

0.575

−0.04

0.157

 18

Neisseria pharyngis

N

–

−2.87 (0.06)

−2.81 (0.13)

− 2.95 (0.09)

−2.80 (0.11)

0.479

0.01

0.760

 19

Fretibacterium sp._oral_taxon_358

U

–

−2.84 (0.07)

−2.87 (0.14)

− 2.88 (0.10)

−2.77 (0.12)

0.708

0.02

0.494

 20

Treponema medium

P

–

−2.79 (0.06)

−2.85 (0.14)

− 2.74 (0.10)

−2.81 (0.10)

0.777

0.02

0.579

  1. *OTUs are ranked according to mean CLR OTU. The 20 most abundant OTUs have positive mean CRL; the 20 least abundant OTUs have negative mean CLR
  2. The CLR OTU can be interpreted as a log [2] fold-difference for the given species relative to the overall compositional geometric mean. A mean CLR of 3 indicates a 8-fold [23] higher abundance, and a mean CLR of −3 indicates a 8-fold lower abundance, relative to the overall compositional geometric mean
  3. SE standard error, Pearson r the Pearson product-moment correlation coefficient
  4. p-values: bolded are significant at alpha .05; asterisk are significant at alpha 0.05 after Bonferroni correction
  5. Culture status annotation in HOMD: N = named; U = unnamed; P = phylotyped
  6. Socransky complex32: R = red; O = orange; P = purple; G = green; Y = yellow; B = blue; −-- = not part of the Socransky classification
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BMC Oral Health

ISSN: 1472-6831

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