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Table 3 Top 20 highest* and lowest* mean CLR OTU for the overall cohort and by age categories, and their linear correlation with age

From: Composition and diversity of the subgingival microbiome and its relationship with age in postmenopausal women: an epidemiologic investigation

Rank Order*OTU LabelCulture StatusSocransky ComplexOverall Cohort (N = 1219)Age Categories (years)Linear Correlation
     50–59 (N = 239)60–69 (N = 554)≥70 (N = 426)p-valuePearson rp-value
CLR OTU
Mean (SE)
CLR OTU
Mean (SE)
CLR OTU
Mean (SE)
CLR OTU
Mean (SE)
20 Most Abundant Species
 1Veillonella disparN8.25 (0.06)8.23 (0.13)8.11 (0.09)8.45 (0.10)0.0450.080.008
 2Streptococcus oralisNY8.06 (0.05)8.40 (0.11)8.06 (0.08)7.87 (0.09)0.002−0.10<.001
 3Veillonella parvulaNP7.60 (0.07)7.48 (0.15)7.45 (0.09)7.86 (0.11)0.0140.100.001
 4Fusobacterium nucleatum_subsp._vincentiiNO6.43 (0.08)6.21 (0.17)6.48 (0.11)6.50 (0.13)0.3560.020.587
 5Selenomonas sputigenaN5.63 (0.08)5.34 (0.17)5.44 (0.12)6.03 (0.14)0.0010.10<.001
 6Fusobacterium nucleatum_subsp._animalisN5.39 (0.07)5.29 (0.14)5.29 (0.10)5.57 (0.12)0.1360.100.106
 7Campylobacter gracilisNO5.19 (0.05)5.02 (0.11)5.15 (0.07)5.33 (0.09)0.0520.100.016
 8Fusobacterium nucleatum_subsp._polymorphumNO5.19 (0.07)5.36 (0.15)5.28 (0.09)4.97 (0.12)0.052−0.100.019
 9Prevotella orisN5.08 (0.09)5.25 (0.18)5.05 (0.13)5.03 (0.16)0.646−0.100.118
 10Streptococcus sanguinisNY4.91 (0.07)5.57 (0.15)5.04 (0.10)4.38 (0.13)<.001*−0.18<.001*
 11Corynebacterium matruchotiiN4.81 (0.07)4.87 (0.17)4.86 (0.10)4.70 (0.12)0.550−0.040.171
 12Selenomonas noxiaN4.81 (0.08)4.63 (0.18)4.69 (0.11)5.06 (0.13)0.0490.10<.001
 13Prevotella nigrescensNO4.31 (0.10)4.48 (0.21)4.28 (0.15)4.26 (0.18)0.714− 0.030.370
 14Parvimonas micraN4.29 (0.08)4.08 (0.17)4.35 (0.11)4.33 (0.12)0.4010.000.967
 15Rothia dentocariosaU4.28 (0.09)4.46 (0.19)4.38 (0.13)4.04 (0.15)0.113−0.100.008
 16Fusobacterium sp._oral_taxon_203N4.23 (0.10)4.08 (0.22)4.36 (0.15)4.16 (0.17)0.497−0.010.713
 17Streptococcus gordoniiNY4.19 (0.08)3.93 (0.18)4.15 (0.12)4.40 (0.13)0.0900.040.039
 18Granulicatella adiacensN4.15 (0.06)4.23 (0.14)4.11 (0.09)4.15 (0.10)0.7490.000.991
 19Streptococcus intermediusNY3.94 (0.10)4.33 (0.21)3.86 (0.15)3.81 (0.16)0.119−0.100.016
 20Actinomyces naeslundiiNB3.85 (0.06)4.00 (0.14)3.88 (0.09)3.72 (0.11)0.230−0.100.008
20 Least Abundant Species
 1Porphyrobacter tepidariusN− 3.58 (0.03)−3.51 (0.08)− 3.65 (0.05)− 3.54 (0.06)0.2160.010.869
 2Sphingomonas sp._oral_taxon_006P− 3.55 (0.04)− 3.49 (0.08)− 3.60 (0.05)− 3.52 (0.06)0.407−0.000.989
 3Pyramidobacter piscolensP− 3.53 (0.04)− 3.44 (0.10)− 3.60 (0.06)− 3.47 (0.07)0.251− 0.010.919
 4Leptothrix sp._oral_taxon_025P−3.50 (0.04)− 3.37 (0.08)− 3.53 (0.06)−3.53 (0.06)0.216−0.040.221
 5Treponema sp._oral_taxon_247P−3.45 (0.05)−3.35 (0.09)− 3.50 (0.07)−3.44 (0.08)0.436− 0.020.566
 6Atopobium sp._oral_taxon_416P−3.38 (0.05)−3.45 (0.09)− 3.44 (0.07)−3.27 (0.09)0.2020.100.042
 7Brevundimonas diminutaN−3.30 (0.04)−3.17 (0.09)− 3.35 (0.06)−3.30 (0.07)0.232−0.030.306
 8Prevotella multiformisN−3.08 (0.06)−3.12 (0.11)− 3.10 (0.09)−3.05 (0.10)0.9010.030.359
 9GN02_[G-2] sp._oral_taxon_873P−3.06 (0.05)−3.08 (0.12)− 3.03 (0.08)−3.10 (0.09)0.851−0.000.927
 10Streptococcus sobrinusU−3.04 (0.06)−3.21 (0.10)− 3.19 (0.09)−2.75 (0.14)0.0050.11<.001*
 11Aggregatibacter actinomycetemcomitansP− 3.01 (0.07)− 2.97 (0.15)− 3.09 (0.10)− 2.94 (0.11)0.5750.030.349
 12Fretibacterium sp._oral_taxon_361P−2.98 (0.06)−3.18 (0.10)−2.97 (0.09)− 2.88 (0.11)0.2070.020.469
 13Butyrivibrio sp._oral_taxon_080P−2.96 (0.06)−2.85 (0.13)− 2.90 (0.09)−3.10 (0.09)0.193−0.100.038
 14Lactobacillus gasseriN−2.95 (0.06)−3.08 (0.12)−3.09 (0.09)−2.70 (0.12)0.0120.100.002
 15Mitsuokella sp._oral_taxon_521N−2.90 (0.06)−2.91 (0.12)− 2.92 (0.08)−2.87 (0.11)0.9290.020.603
 16Microbacterium flavescensP−2.89 (0.04)−2.73 (0.09)− 2.89 (0.06)−2.97 (0.07)0.151−0.100.051
 17Prevotella sp._oral_taxon_475N−2.87 (0.06)−2.81 (0.12)− 2.84 (0.09)−2.95 (0.09)0.575−0.040.157
 18Neisseria pharyngisN−2.87 (0.06)−2.81 (0.13)− 2.95 (0.09)−2.80 (0.11)0.4790.010.760
 19Fretibacterium sp._oral_taxon_358U−2.84 (0.07)−2.87 (0.14)− 2.88 (0.10)−2.77 (0.12)0.7080.020.494
 20Treponema mediumP−2.79 (0.06)−2.85 (0.14)− 2.74 (0.10)−2.81 (0.10)0.7770.020.579
  1. *OTUs are ranked according to mean CLR OTU. The 20 most abundant OTUs have positive mean CRL; the 20 least abundant OTUs have negative mean CLR
  2. The CLR OTU can be interpreted as a log [2] fold-difference for the given species relative to the overall compositional geometric mean. A mean CLR of 3 indicates a 8-fold [23] higher abundance, and a mean CLR of −3 indicates a 8-fold lower abundance, relative to the overall compositional geometric mean
  3. SE standard error, Pearson r the Pearson product-moment correlation coefficient
  4. p-values: bolded are significant at alpha .05; asterisk are significant at alpha 0.05 after Bonferroni correction
  5. Culture status annotation in HOMD: N = named; U = unnamed; P = phylotyped
  6. Socransky complex32: R = red; O = orange; P = purple; G = green; Y = yellow; B = blue; −-- = not part of the Socransky classification