Skip to main content

Table 4 Mean CLR OTUs for each of 267 bacterial species in the overall cohort and by age categories, and its linear correlation with age

From: Composition and diversity of the subgingival microbiome and its relationship with age in postmenopausal women: an epidemiologic investigation

Rank Order*OTU LabelCulture StatusSocransky ComplexOverall
Cohort
(N = 1219)
Age Categories (years)Linear Correlation
    CLR OTU
Mean (SE)
50–59
(N = 239)
CLR OTU
Mean (SE)
60–69
(N = 554)
CLR OTU
Mean (SE)
≥70
(N = 426)
CLR OTU
Mean (SE)
p-valuePearson rp-value
1Veillonella disparN8.25 (0.06)8.23 (0.13)8.11 (0.09)8.45 (0.10)0.0450.080.008
2Streptococcus oralisNY8.06 (0.05)8.40 (0.11)8.06 (0.08)7.87 (0.09)0.002−0.10<.001
3Veillonella parvulaNP7.60 (0.07)7.48 (0.15)7.45 (0.09)7.86 (0.11)0.0140.100.001
4Fusobacterium nucleatum_subsp._vincentiiNO6.43 (0.08)6.21 (0.17)6.48 (0.11)6.50 (0.13)0.3560.020.587
5Selenomonas sputigenaN5.63 (0.08)5.34 (0.17)5.44 (0.12)6.03 (0.14)0.0010.10<.001
6Fusobacterium nucleatum_subsp._animalisN5.39 (0.07)5.29 (0.14)5.29 (0.10)5.57 (0.12)0.1360.100.106
7Campylobacter gracilisNO5.19 (0.05)5.02 (0.11)5.15 (0.07)5.33 (0.09)0.0520.100.016
8Fusobacterium nucleatum_subsp._polymorphumNO5.19 (0.07)5.36 (0.15)5.28 (0.09)4.97 (0.12)0.052−0.100.019
9Prevotella orisN5.08 (0.09)5.25 (0.18)5.05 (0.13)5.03 (0.16)0.646−0.100.118
10Streptococcus sanguinisNY4.91 (0.07)5.57 (0.15)5.04 (0.10)4.38 (0.13)<.001*−0.18<.001*
11Corynebacterium matruchotiiN4.81 (0.07)4.87 (0.17)4.86 (0.10)4.70 (0.12)0.550−0.040.171
12Selenomonas noxiaN4.81 (0.08)4.63 (0.18)4.69 (0.11)5.06 (0.13)0.0490.10<.001
13Prevotella nigrescensNO4.31 (0.10)4.48 (0.21)4.28 (0.15)4.26 (0.18)0.714−0.030.370
14Parvimonas micraN4.29 (0.08)4.08 (0.17)4.35 (0.11)4.33 (0.12)0.4010.000.967
15Rothia dentocariosaU4.28 (0.09)4.46 (0.19)4.38 (0.13)4.04 (0.15)0.113−0.100.008
16Fusobacterium sp._oral_taxon_203N4.23 (0.10)4.08 (0.22)4.36 (0.15)4.16 (0.17)0.497−0.010.713
17Streptococcus gordoniiNY4.19 (0.08)3.93 (0.18)4.15 (0.12)4.40 (0.13)0.0900.040.039
18Granulicatella adiacensN4.15 (0.06)4.23 (0.14)4.11 (0.09)4.15 (0.10)0.7490.000.991
19Streptococcus intermediusNY3.94 (0.10)4.33 (0.21)3.86 (0.15)3.81 (0.16)0.119−0.100.016
20Actinomyces naeslundiiNB3.85 (0.06)4.00 (0.14)3.88 (0.09)3.72 (0.11)0.230−0.100.008
21TM7_[G-1] sp._oral_taxon_346P3.78 (0.09)3.63 (0.19)3.90 (0.12)3.70 (0.16)0.4210.000.917
22Haemophilus parainfluenzaeN3.74 (0.09)4.21 (0.19)3.73 (0.13)3.48 (0.15)0.014−0.100.004
23Fusobacterium naviformeN3.58 (0.08)3.61 (0.18)3.62 (0.12)3.52 (0.14)0.852−0.030.294
24Dialister invisusN3.51 (0.08)3.12 (0.16)3.50 (0.11)3.75 (0.13)0.0130.100.003
25Capnocytophaga gingivalisNG3.36 (0.08)3.39 (0.18)3.45 (0.11)3.23 (0.13)0.423−0.040.172
26Streptococcus cristatusN3.27 (0.07)3.17 (0.16)3.27 (0.11)3.32 (0.13)0.7760.010.754
27Gemella morbillorumN3.14 (0.09)3.37 (0.20)3.35 (0.13)2.73 (0.16)0.004−0.11<.001*
28Streptococcus salivariusU3.02 (0.08)3.05 (0.18)2.79 (0.13)3.29 (0.14)0.0280.100.090
29TM7_[G-1] sp._oral_taxon_349N2.99 (0.10)2.71 (0.22)3.15 (0.14)2.95 (0.18)0.2510.040.204
30Bacteroidales_[G-2] sp._oral_taxon_274N2.96 (0.10)2.47 (0.22)3.15 (0.14)3.00 (0.16)0.0300.030.328
31Campylobacter showaePO2.89 (0.08)3.00 (0.17)2.81 (0.11)2.93 (0.14)0.609−0.010.685
32Veillonella atypicaN2.88 (0.09)2.47 (0.20)2.56 (0.13)3.53 (0.14)<.001*0.16<.001*
33Eikenella corrodensN2.87 (0.07)3.00 (0.15)3.07 (0.10)2.53 (0.12)0.001−0.11<.001*
34Capnocytophaga leadbetteriN2.86 (0.09)2.87 (0.20)2.93 (0.13)2.78 (0.16)0.758−0.030.334
35Fretibacterium sp._oral_taxon_360N2.81 (0.11)2.29 (0.23)2.89 (0.16)3.00 (0.19)0.0480.040.148
36Prevotella sp._oral_taxon_317N2.73 (0.10)2.79 (0.22)2.68 (0.16)2.76 (0.18)0.907−0.000.965
37Capnocytophaga granulosaU2.72 (0.09)2.39 (0.21)2.84 (0.13)2.75 (0.16)0.1890.040.152
38Alloprevotella tanneraeN2.71 (0.12)2.69 (0.24)2.78 (0.17)2.64 (0.20)0.8650.010.788
39Kingella oralisP2.66 (0.08)2.66 (0.19)2.65 (0.11)2.68 (0.14)0.983−0.010.847
40TM7_[G-1] sp._oral_taxon_952U2.58 (0.10)2.80 (0.22)2.83 (0.14)2.12 (0.16)0.002−0.10<.001
41Selenomonas artemidisN2.51 (0.11)2.77 (0.24)2.39 (0.16)2.52 (0.19)0.419−0.000.957
42Campylobacter concisusNG2.41 (0.06)2.22 (0.14)2.37 (0.10)2.56 (0.11)0.1520.100.036
43Actinomyces orisNB2.36 (0.08)2.63 (0.17)2.37 (0.11)2.18 (0.13)0.104−0.100.021
44Treponema socranskiiN2.22 (0.07)1.84 (0.17)2.16 (0.11)2.52 (0.13)0.0040.10<.001
45Cardiobacterium hominisN2.21 (0.08)2.50 (0.19)2.45 (0.12)1.75 (0.14)<.001*−0.11<.001
46Leptotrichia wadeiN2.15 (0.10)2.21 (0.23)1.94 (0.16)2.38 (0.18)0.1590.030.305
47Anaeroglobus geminatusP2.12 (0.10)1.32 (0.22)1.94 (0.15)2.79 (0.18)<.001*0.17<.001*
48Gemella haemolysansN2.11 (0.09)2.42 (0.20)2.10 (0.13)1.96 (0.14)0.161−0.100.018
49Capnocytophaga sputigenaNG2.11 (0.09)2.31 (0.21)2.23 (0.13)1.84 (0.17)0.113−0.100.094
50Rothia aeriaN2.11 (0.09)2.49 (0.20)2.42 (0.14)1.48 (0.15)<.001*−0.15<.001*
51Bergeyella sp._oral_taxon_322N2.08 (0.07)2.38 (0.16)2.11 (0.10)1.87 (0.11)0.028−0.100.008
52Leptotrichia hongkongensisN2.02 (0.09)2.02 (0.21)1.94 (0.14)2.13 (0.16)0.6600.030.337
53Rothia mucilaginosaU1.95 (0.08)1.79 (0.17)1.90 (0.11)2.09 (0.13)0.3210.030.237
54Prevotella melaninogenicaN1.90 (0.08)1.75 (0.17)1.78 (0.12)2.14 (0.14)0.0950.100.049
55Actinomyces sp._oral_taxon_169N1.89 (0.09)2.28 (0.20)1.96 (0.13)1.59 (0.15)0.016−0.10<.001
56Tannerella forsythiaNR1.87 (0.10)1.50 (0.21)1.80 (0.14)2.18 (0.17)0.0420.100.029
57Selenomonas sp._oral_taxon_136N1.86 (0.08)1.21 (0.18)1.76 (0.12)2.36 (0.15)<.001*0.16<.001*
58Catonella morbiN1.86 (0.08)2.08 (0.17)1.89 (0.11)1.69 (0.13)0.184−0.100.020
59Prevotella denticolaN1.74 (0.10)1.46 (0.23)1.60 (0.15)2.10 (0.18)0.0400.100.006
60Neisseria siccaN1.72 (0.11)1.58 (0.25)1.88 (0.16)1.60 (0.18)0.416−0.010.678
61Peptostreptococcaceae_[XI][G-9] [Eubacterium]_bracU1.70 (0.08)2.08 (0.16)1.72 (0.12)1.47 (0.14)0.030−0.100.003
62Neisseria elongataN1.63 (0.10)1.95 (0.25)1.81 (0.15)1.22 (0.17)0.012−0.100.008
63Cardiobacterium valvarumU1.49 (0.09)1.60 (0.21)1.63 (0.13)1.26 (0.14)0.137−0.100.044
64Porphyromonas sp._oral_taxon_279P1.49 (0.09)1.46 (0.20)1.62 (0.13)1.34 (0.16)0.394−0.020.494
65Selenomonas infelixU1.48 (0.08)1.56 (0.17)1.44 (0.12)1.50 (0.15)0.871−0.010.709
66Leptotrichia sp._oral_taxon_212U1.44 (0.09)1.63 (0.21)1.64 (0.13)1.08 (0.16)0.013−0.100.011
67Actinomyces sp._oral_taxon_180N1.44 (0.07)1.54 (0.15)1.45 (0.10)1.38 (0.11)0.704−0.030.235
68Prevotella sp._oral_taxon_300N1.43 (0.09)1.31 (0.19)1.24 (0.13)1.75 (0.15)0.0250.100.007
69Prevotella maculosaN1.42 (0.08)1.07 (0.17)1.32 (0.11)1.75 (0.13)0.0030.100.001
70Streptococcus mutansN1.39 (0.11)0.98 (0.24)1.19 (0.16)1.87 (0.20)0.0050.10<.001
71Actinomyces massiliensisNB1.38 (0.07)1.68 (0.17)1.50 (0.10)1.05 (0.11)0.002−0.12<.001*
72Fretibacterium fastidiosumN1.30 (0.10)1.12 (0.22)1.25 (0.15)1.47 (0.17)0.3930.040.173
73Veillonellaceae_[G-1] sp._oral_taxon_150N1.23 (0.09)0.74 (0.20)1.00 (0.13)1.81 (0.16)<.001*0.14<.001*
74Neisseria flavescensN1.23 (0.10)0.98 (0.21)1.28 (0.14)1.30 (0.17)0.4250.020.533
75Prevotella oulorumP1.22 (0.09)1.23 (0.20)1.00 (0.13)1.50 (0.15)0.0410.100.059
76Streptococcus anginosusNY1.17 (0.11)1.03 (0.23)0.92 (0.16)1.56 (0.19)0.0240.100.013
77Lachnoanaerobaculum saburreumN1.07 (0.08)0.85 (0.18)1.12 (0.12)1.13 (0.14)0.3840.040.208
78Veillonellaceae_[G-1] sp._oral_taxon_155N1.00 (0.09)0.66 (0.20)0.84 (0.13)1.39 (0.15)0.0040.10<.001
79Selenomonas sp._oral_taxon_892L0.98 (0.08)1.18 (0.19)1.05 (0.12)0.76 (0.15)0.148−0.100.030
80Actinomyces johnsoniiNB0.97 (0.07)1.18 (0.16)0.92 (0.11)0.92 (0.12)0.365−0.040.229
81Selenomonas sp._oral_taxon_137U0.95 (0.11)0.95 (0.25)1.21 (0.17)0.61 (0.20)0.064−0.040.145
82Corynebacterium durumU0.93 (0.08)1.53 (0.19)1.07 (0.12)0.42 (0.13)<.001*−0.15<.001*
83Lautropia mirabilisU0.88 (0.09)1.28 (0.21)0.99 (0.13)0.53 (0.15)0.006−0.10<.001
84Veillonella rogosaeN0.87 (0.09)1.06 (0.20)1.08 (0.13)0.49 (0.16)0.010−0.10<.001
85Leptotrichia sp._oral_taxon_417N0.86 (0.09)0.41 (0.20)0.95 (0.13)1.01 (0.16)0.0480.100.006
86Selenomonas flueggeiN0.81 (0.08)0.58 (0.18)0.81 (0.12)0.93 (0.14)0.3170.040.122
87Selenomonas sp._oral_taxon_134P0.77 (0.10)0.55 (0.21)0.75 (0.14)0.94 (0.18)0.3670.030.251
88Streptococcus parasanguinis_IIU0.74 (0.09)0.58 (0.19)0.49 (0.13)1.15 (0.15)0.0030.11<.001*
89Megasphaera micronuciformisN0.70 (0.08)0.47 (0.19)0.46 (0.13)1.14 (0.14)<.0010.12<.001*
90Capnocytophaga sp._oral_taxon_336N0.69 (0.09)0.68 (0.19)0.69 (0.13)0.71 (0.16)0.9910.020.480
91Oribacterium sp._oral_taxon_078U0.66 (0.08)−0.03 (0.17)0.51 (0.11)1.26 (0.14)<.001*0.18<.001*
92Actinomyces sp._oral_taxon_171P0.66 (0.08)0.82 (0.18)0.66 (0.12)0.57 (0.13)0.527−0.100.090
93Lachnospiraceae_[G-3] sp._oral_taxon_100U0.59 (0.08)0.60 (0.18)0.73 (0.12)0.41 (0.14)0.200−0.030.239
94Parvimonas sp._oral_taxon_393U0.58 (0.11)1.11 (0.24)0.63 (0.16)0.22 (0.17)0.010−0.12<.001*
95Actinomyces gerencseriaeNB0.56 (0.07)0.49 (0.17)0.37 (0.11)0.86 (0.13)0.0120.100.008
96Dialister pneumosintesP0.55 (0.09)0.64 (0.20)0.42 (0.14)0.65 (0.16)0.4770.030.357
97Kingella denitrificansN0.54 (0.09)0.21 (0.20)0.45 (0.13)0.84 (0.15)0.0250.100.024
98Porphyromonas endodontalisN0.52 (0.12)1.09 (0.27)0.56 (0.17)0.13 (0.20)0.015−0.10<.001
99TM7_[G-5] sp._oral_taxon_356P0.49 (0.11)0.30 (0.23)0.61 (0.16)0.43 (0.19)0.5170.020.580
100Selenomonas sp._oral_taxon_919U0.47 (0.08)0.72 (0.18)0.45 (0.12)0.35 (0.15)0.287−0.100.096
101Leptotrichia buccalisN0.45 (0.10)0.23 (0.23)0.77 (0.14)0.16 (0.16)0.011−0.030.375
102Prevotella sp._oral_taxon_472N0.45 (0.10)0.65 (0.23)0.80 (0.15)−0.13 (0.17)<.001*−0.10<.001
103Capnocytophaga sp._oral_taxon_326P0.41 (0.10)0.38 (0.23)0.62 (0.15)0.15 (0.17)0.121−0.100.080
104Streptococcus constellatusNO0.35 (0.10)0.25 (0.21)0.18 (0.15)0.63 (0.17)0.1140.040.139
105Prevotella salivaeN0.34 (0.08)−0.22 (0.18)0.32 (0.12)0.69 (0.14)<.0010.15<.001*
106Leptotrichia sp._oral_taxon_392U0.33 (0.09)0.49 (0.20)0.58 (0.13)− 0.08 (0.15)0.003−0.100.001
107Actinobaculum sp._oral_taxon_183N0.32 (0.08)0.29 (0.17)0.28 (0.12)0.40 (0.14)0.7650.010.742
108Neisseria oralisU0.31 (0.11)0.47 (0.25)0.35 (0.15)0.19 (0.18)0.618−0.040.133
109Atopobium rimaeN0.21 (0.09)−0.08 (0.19)0.17 (0.13)0.43 (0.16)0.1240.100.108
110Leptotrichia hofstadiiN0.20 (0.10)0.10 (0.22)0.27 (0.15)0.17 (0.17)0.8040.010.743
111Streptococcus sp._oral_taxon_074N0.15 (0.07)0.15 (0.16)0.25 (0.11)0.02 (0.12)0.340−0.040.154
112Fretibacterium sp._oral_taxon_359L0.15 (0.11)0.14 (0.25)0.04 (0.16)0.30 (0.18)0.5370.020.552
113Leptotrichia shahiiU0.11 (0.10)0.30 (0.22)−0.09 (0.15)0.26 (0.19)0.2090.030.298
114Tannerella sp._oral_taxon_286U0.11 (0.07)− 0.15 (0.16)0.26 (0.10)0.06 (0.13)0.1010.030.370
115Porphyromonas sp._oral_taxon_284N0.08 (0.10)0.14 (0.21)0.22 (0.14)− 0.14 (0.16)0.223−0.100.080
116Peptostreptococcaceae_[XI][G-7] [Eubacterium]_yuriP0.05 (0.10)0.50 (0.21)0.19 (0.14)−0.40 (0.16)0.001−0.14<.001*
117Selenomonas sp._oral_taxon_146L0.04 (0.08)0.04 (0.18)− 0.03 (0.12)0.14 (0.14)0.6590.0140.633
118Fusobacterium periodonticumNO−0.02 (0.07)−0.12 (0.16)0.13 (0.11)−0.17 (0.13)0.174−0.020.488
119Actinomyces meyeriLB−0.04 (0.08)0.29 (0.18)0.05 (0.12)− 0.35 (0.13)0.010−0.11<.001*
120Leptotrichia sp._oral_taxon_215N− 0.05 (0.08)0.16 (0.18)0.01 (0.12)− 0.24 (0.14)0.157−0.040.170
121Prevotella oralisN− 0.06 (0.10)−0.34 (0.20)− 0.13 (0.14)0.20 (0.17)0.1050.100.030
122Prevotella pleuritidisN− 0.10 (0.12)−0.07 (0.27)0.09 (0.18)−0.38 (0.20)0.211−0.040.190
123Abiotrophia defectivaN−0.15 (0.09)−0.05 (0.19)− 0.01 (0.13)− 0.38 (0.14)0.138− 0.100.028
124Gemella sanguinisN−0.19 (0.07)−0.16 (0.15)− 0.35 (0.10)− 0.00 (0.12)0.0770.040.204
125Fusobacterium nucleatum_subsp._nucleatumNO−0.25 (0.08)−0.44 (0.17)− 0.30 (0.11)− 0.08 (0.14)0.2090.030.259
126Atopobium parvulumN− 0.25 (0.08)−0.28 (0.17)− 0.47 (0.11)0.06 (0.14)0.0090.100.005
127Aggregatibacter sp._oral_taxon_458N− 0.25 (0.09)− 0.11 (0.19)− 0.17 (0.13)− 0.44 (0.15)0.309−0.100.047
128Streptococcus parasanguinis_IN− 0.26 (0.08)−0.29 (0.17)− 0.48 (0.11)0.05 (0.13)0.0080.100.008
129Aggregatibacter aphrophilusN− 0.27 (0.11)−0.18 (0.25)− 0.01 (0.17)− 0.66 (0.18)0.027− 0.100.015
130Treponema denticolaNR−0.28 (0.10)−0.16 (0.22)− 0.25 (0.15)− 0.39 (0.18)0.692− 0.040.211
131Prevotella saccharolyticaU− 0.37 (0.07)− 0.38 (0.16)− 0.26 (0.11)− 0.51 (0.13)0.336− 0.010.663
132TM7_[G-1] sp._oral_taxon_488P− 0.39 (0.10)− 0.39 (0.22)− 0.11 (0.15)− 0.76 (0.16)0.015−0.040.132
133Johnsonella ignavaU− 0.41 (0.09)−0.50 (0.21)− 0.34 (0.14)− 0.45 (0.16)0.783− 0.010.783
134Actinomyces israeliiNB−0.47 (0.06)−0.65 (0.13)− 0.52 (0.09)− 0.30 (0.11)0.0910.100.012
135Lachnoanaerobaculum umeaenseP− 0.47 (0.07)−0.35 (0.17)− 0.39 (0.11)− 0.65 (0.12)0.198−0.030.316
136Streptococcus sp._oral_taxon_056U− 0.49 (0.08)−0.38 (0.19)− 0.37 (0.12)− 0.73 (0.14)0.127−0.040.050
137Olsenella sp._oral_taxon_807N− 0.49 (0.07)−0.93 (0.15)− 0.50 (0.10)− 0.25 (0.12)0.0020.11<.001*
138Solobacterium mooreiU− 0.51 (0.06)−0.49 (0.15)− 0.60 (0.09)− 0.42 (0.11)0.4370.040.221
139Treponema maltophilumP− 0.53 (0.08)−0.78 (0.16)− 0.59 (0.11)− 0.32 (0.13)0.0700.100.040
140TM7_[G-1] sp._oral_taxon_348N− 0.53 (0.08)− 0.66 (0.17)− 0.29 (0.13)− 0.77 (0.14)0.026− 0.030.373
141Porphyromonas gingivalisNR−0.56 (0.12)−0.70 (0.26)− 0.60 (0.17)− 0.43 (0.22)0.6880.030.348
142Centipeda periodontiiN− 0.60 (0.08)− 0.94 (0.15)− 0.55 (0.11)− 0.47 (0.13)0.0740.060.031
143Selenomonas sp._oral_taxon_126N− 0.60 (0.08)−0.77 (0.18)− 0.56 (0.12)− 0.56 (0.14)0.5880.030.386
144Desulfobulbus sp._oral_taxon_041U−0.66 (0.10)−1.02 (0.20)− 0.70 (0.14)− 0.40 (0.17)0.0640.100.027
145Alloprevotella ravaU−0.68 (0.08)−0.78 (0.18)− 0.64 (0.12)− 0.69 (0.14)0.8090.020.464
146Actinobaculum sp._oral_taxon_848P− 0.70 (0.08)−0.83 (0.17)− 0.82 (0.11)−0.46 (0.13)0.0800.100.016
147Stomatobaculum longumN− 0.70 (0.07)− 0.95 (0.16)− 0.76 (0.11)−0.48 (0.13)0.0540.11<.001
148Prevotella histicolaN− 0.75 (0.09)− 0.96 (0.18)−1.04 (0.13)− 0.26 (0.16)<.0010.11<.001*
149Aggregatibacter segnisU− 0.79 (0.10)− 0.42 (0.22)− 0.69 (0.14)−1.13 (0.15)0.020− 0.11<.001*
150Leptotrichia sp._oral_taxon_225N− 0.80 (0.10)− 0.43 (0.22)− 0.60 (0.15)− 1.25 (0.15)0.002− 0.11<.001*
151Ruminococcaceae_[G-1] sp._oral_taxon_075N− 0.80 (0.08)− 0.79 (0.17)− 0.69 (0.12)−0.94 (0.13)0.350−0.030.341
152Peptostreptococcus stomatisU− 0.80 (0.09)−0.50 (0.19)− 0.77 (0.13)− 1.02 (0.14)0.085− 0.100.032
153Porphyromonas catoniaeP− 0.92 (0.09)− 0.50 (0.20)− 0.79 (0.13)−1.31 (0.14)0.002− 0.10<.001
154Actinomyces sp._oral_taxon_178P−0.93 (0.06)− 1.15 (0.14)− 0.94 (0.09)− 0.78 (0.10)0.0990.050.080
155Prevotella pallensN− 0.93 (0.08)−1.00 (0.17)− 1.05 (0.11)−0.73 (0.14)0.1910.100.054
156Filifactor alocisU− 0.94 (0.10)−0.66 (0.23)− 0.98 (0.15)− 1.05 (0.18)0.382− 0.100.077
157Selenomonas sp._oral_taxon_936P−0.96 (0.08)− 0.91 (0.17)−1.05 (0.12)− 0.87 (0.14)0.5780.030.323
158TM7_[G-1] sp._oral_taxon_347N− 0.97 (0.09)−0.64 (0.20)− 0.95 (0.14)−1.17 (0.14)0.107− 0.100.071
159Haemophilus sp._oral_taxon_036N−1.01 (0.09)− 0.65 (0.19)− 1.00 (0.13)− 1.21 (0.15)0.075− 0.100.002
160Prevotella sp._oral_taxon_292P− 1.06 (0.08)− 1.34 (0.17)− 1.15 (0.12)−0.79 (0.15)0.0400.100.001
161Leptotrichia sp._oral_taxon_498N− 1.07 (0.09)−1.28 (0.20)− 1.20 (0.13)−0.77 (0.16)0.0590.100.013
162Capnocytophaga sp._oral_taxon_338U− 1.08 (0.09)−1.17 (0.20)− 1.12 (0.13)−0.98 (0.15)0.6710.010.808
163Alloprevotella sp._oral_taxon_308N− 1.14 (0.07)−0.90 (0.14)−1.28 (0.10)− 1.10 (0.12)0.111−0.010.799
164Treponema sp._oral_taxon_231P− 1.15 (0.09)−1.04 (0.18)− 1.03 (0.13)− 1.36 (0.15)0.206− 0.100.074
165TM7_[G-1] sp._oral_taxon_352N− 1.15 (0.07)− 1.31 (0.15)− 1.11 (0.10)− 1.11 (0.12)0.5450.040.173
166Prevotella buccaeU− 1.23 (0.07)−1.71 (0.14)− 1.36 (0.11)− 0.78 (0.12)<.001*0.14<.001*
167Prevotella loescheiiN−1.24 (0.09)−0.96 (0.21)−0.97 (0.14)− 1.74 (0.15)<.001− 0.100.001
168Capnocytophaga sp._oral_taxon_864U− 1.27 (0.08)−0.98 (0.20)−1.15 (0.13)− 1.57 (0.13)0.020− 0.100.005
169Actinomyces sp._oral_taxon_170U−1.29 (0.08)− 0.99 (0.19)− 1.16 (0.13)− 1.62 (0.13)0.011− 0.10<.001
170Lachnoanaerobaculum oraleU− 1.31 (0.07)− 1.09 (0.16)− 1.46 (0.09)−1.23 (0.12)0.0850.020.513
171Ottowia sp._oral_taxon_894N− 1.31 (0.08)−1.44 (0.18)− 1.24 (0.12)− 1.33 (0.14)0.662−0.000.938
172Streptococcus lactariusN− 1.32 (0.07)− 1.06 (0.15)− 1.46 (0.10)− 1.30 (0.12)0.097−0.020.414
173Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infiP− 1.33 (0.07)− 1.59 (0.15)− 1.41 (0.09)− 1.08 (0.12)0.0140.100.002
174Leptotrichia sp._oral_taxon_219N− 1.34 (0.07)−1.39 (0.17)− 1.27 (0.11)−1.39 (0.12)0.736−0.010.717
175Prevotella intermediaPO−1.36 (0.11)−1.31 (0.25)− 1.35 (0.17)− 1.41 (0.18)0.943−0.040.181
176Veillonella denticariosiU− 1.37 (0.09)− 1.51 (0.19)− 1.39 (0.13)− 1.27 (0.15)0.6210.040.156
177Fretibacterium sp._oral_taxon_362N− 1.43 (0.08)−1.48 (0.19)− 1.43 (0.12)− 1.42 (0.14)0.9650.000.888
178Bacteroidetes_[G-5] sp._oral_taxon_511U− 1.47 (0.09)− 1.44 (0.19)− 1.43 (0.14)− 1.54 (0.15)0.846−0.030.378
179Prevotella sp._oral_taxon_313P− 1.49 (0.08)−1.14 (0.18)− 1.75 (0.11)− 1.35 (0.14)0.0070.020.431
180TM7_[G-3] sp._oral_taxon_351P− 1.50 (0.06)−1.84 (0.13)− 1.39 (0.10)− 1.45 (0.11)0.0290.100.018
181Streptococcus australisN− 1.51 (0.07)−1.62 (0.15)− 1.57 (0.11)− 1.38 (0.13)0.3730.030.295
182Granulicatella elegansN− 1.59 (0.07)−1.18 (0.17)− 1.72 (0.11)−1.65 (0.12)0.023−0.100.067
183TM7_[G-1] sp._oral_taxon_869P− 1.60 (0.09)−1.64 (0.20)− 1.55 (0.14)− 1.64 (0.15)0.8900.010.663
184Capnocytophaga sp._oral_taxon_902N−1.65 (0.08)− 1.56 (0.19)− 1.68 (0.12)−1.67 (0.14)0.860−0.040.220
185Prevotella dentalisP−1.66 (0.08)−1.65 (0.19)− 1.82 (0.12)−1.47 (0.14)0.1800.030.326
186Campylobacter curvusN− 1.67 (0.07)−1.57 (0.17)− 1.79 (0.10)− 1.58 (0.13)0.3650.030.335
187Pseudoramibacter alactolyticusP− 1.68 (0.08)− 2.18 (0.17)−1.73 (0.12)− 1.35 (0.15)0.0010.12<.001*
188TM7_[G-6] sp._oral_taxon_870N− 1.71 (0.08)−1.47 (0.18)− 1.69 (0.12)− 1.85 (0.13)0.220−0.100.085
189Veillonellaceae_[G-1] sp._oral_taxon_129N− 1.71 (0.08)− 1.96 (0.16)− 1.80 (0.11)− 1.46 (0.14)0.0420.100.010
190Tannerella sp._oral_taxon_808U− 1.75 (0.07)−2.03 (0.14)−1.70 (0.10)− 1.65 (0.12)0.1040.100.011
191Peptostreptococcaceae_[XI][G-6] [Eubacterium]_nodaL− 1.75 (0.08)− 1.67 (0.18)− 1.90 (0.11)−1.61 (0.14)0.2380.020.425
192Mitsuokella sp._oral_taxon_131N− 1.79 (0.09)−2.18 (0.17)− 1.96 (0.13)− 1.36 (0.16)<.0010.14<.001*
193Mycoplasma salivariumP− 1.80 (0.07)−1.77 (0.15)− 1.87 (0.11)− 1.71 (0.12)0.5790.030.302
194Haemophilus haemolyticusP− 1.81 (0.08)−1.30 (0.19)− 1.92 (0.12)− 1.94 (0.12)0.006−0.100.043
195Bergeyella sp._oral_taxon_907P−1.81 (0.07)−1.86 (0.15)− 1.72 (0.10)− 1.92 (0.12)0.405− 0.010.765
196TM7_[G-2] sp._oral_taxon_350N− 1.82 (0.09)− 1.86 (0.18)− 1.82 (0.13)− 1.80 (0.15)0.9680.020.412
197Prevotella veroralisU− 1.82 (0.08)−1.73 (0.18)− 1.78 (0.13)− 1.93 (0.13)0.582−0.020.413
198Aggregatibacter paraphrophilusN− 1.82 (0.09)−1.48 (0.21)− 1.69 (0.14)−2.19 (0.13)0.007−0.10<.001
199Leptotrichia sp._oral_taxon_223P− 1.82 (0.08)−1.71 (0.17)− 1.98 (0.11)− 1.69 (0.14)0.2060.020.499
200Bifidobacterium dentiumN− 1.85 (0.08)−2.10 (0.18)−2.12 (0.12)−1.37 (0.15)<.001*0.15<.001*
201Alloprevotella sp._oral_taxon_473U− 1.87 (0.08)−1.63 (0.17)− 1.88 (0.12)− 1.98 (0.13)0.300−0.100.030
202Veillonellaceae_[G-1] sp._oral_taxon_145U− 1.88 (0.08)−1.98 (0.16)− 1.83 (0.12)− 1.88 (0.14)0.7680.020.551
203Neisseria bacilliformisN−1.89 (0.09)−1.82 (0.20)− 1.90 (0.13)− 1.93 (0.14)0.906−0.040.194
204Capnocytophaga sp._oral_taxon_412N− 1.89 (0.08)−1.74 (0.18)− 1.81 (0.12)−2.09 (0.13)0.173− 0.040.162
205Neisseria subflavaN− 1.89 (0.09)− 1.84 (0.18)−2.04 (0.13)− 1.73 (0.16)0.2670.100.118
206Veillonella sp._oral_taxon_780N− 1.94 (0.08)− 1.46 (0.20)− 1.93 (0.12)− 2.20 (0.12)0.004−0.10<.001
207Lachnospiraceae_[G-8] sp._oral_taxon_500N− 1.94 (0.07)−1.91 (0.16)−2.03 (0.10)− 1.83 (0.12)0.4430.010.695
208Capnocytophaga sp._oral_taxon_323P−1.94 (0.08)−1.99 (0.17)− 1.93 (0.12)− 1.94 (0.14)0.966− 0.010.731
209Scardovia wiggsiaeP−1.94 (0.09)− 2.07 (0.19)− 2.11 (0.12)− 1.66 (0.16)0.0610.100.009
210Sphingomonas echinoidesN− 1.95 (0.06)−1.75 (0.14)− 1.89 (0.10)− 2.15 (0.11)0.056−0.10<.001
211SR1_[G-1] sp._oral_taxon_874U− 1.99 (0.07)−1.76 (0.15)− 1.88 (0.10)−2.26 (0.11)0.008−0.100.006
212Treponema lecithinolyticumU−2.01 (0.08)−1.98 (0.17)− 1.90 (0.12)− 2.18 (0.13)0.302−0.100.068
213Prevotella baroniaeP−2.04 (0.07)−2.20 (0.15)− 2.03 (0.11)− 1.96 (0.13)0.4900.040.209
214Pseudomonas fluorescensP− 2.05 (0.07)− 2.12 (0.15)− 2.07 (0.11)−1.98 (0.13)0.7670.030.334
215Shuttleworthia satellesP− 2.08 (0.07)− 2.27 (0.14)− 2.21 (0.10)−1.82 (0.12)0.0160.10<.001
216Prevotella sp._oral_taxon_306U −2.08 (0.07)−2.32 (0.14)− 2.21 (0.10)−1.79 (0.13)0.0100.10<.001
217Porphyromonas sp._oral_taxon_275N− 2.11 (0.07)−2.09 (0.16)− 2.01 (0.12)− 2.26 (0.12)0.321−0.040.184
218Streptococcus sinensisP− 2.14 (0.06)− 1.95 (0.13)− 2.30 (0.08)− 2.05 (0.11)0.0500.020.517
219Anaerolineae_[G-1] sp._oral_taxon_439N− 2.14 (0.08)− 2.47 (0.15)− 2.22 (0.11)−1.85 (0.14)0.0080.12<.001*
220Bacteroidaceae_[G-1] sp._oral_taxon_272N− 2.15 (0.07)− 2.48 (0.15)− 2.21 (0.10)−1.87 (0.13)0.0070.10<.001
221Prevotella micansN− 2.15 (0.07)−2.24 (0.14)− 2.18 (0.10)− 2.08 (0.12)0.6580.020.452
222Leptotrichia goodfellowiiU− 2.17 (0.07)−1.90 (0.17)−2.14 (0.11)− 2.36 (0.12)0.080−0.100.008
223Capnocytophaga sp._oral_taxon_903N− 2.17 (0.08)−2.15 (0.17)− 2.12 (0.11)− 2.25 (0.13)0.751− 0.010.731
224Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphU− 2.18 (0.08)−2.46 (0.15)− 2.13 (0.12)− 2.08 (0.13)0.1950.040.229
225Treponema sp._oral_taxon_237P− 2.20 (0.08)−1.68 (0.19)−2.21 (0.12)− 2.46 (0.13)0.003−0.11<.001*
226Fusobacterium sp._oral_taxon_370U− 2.20 (0.06)−2.25 (0.12)− 2.08 (0.09)− 2.32 (0.10)0.176−0.040.176
227Atopobium sp._oral_taxon_199U− 2.26 (0.07)−2.19 (0.16)− 2.18 (0.11)− 2.40 (0.12)0.334−0.020.433
228Prevotella sp._oral_taxon_314N− 2.28 (0.07)− 2.29 (0.16)− 2.35 (0.11)− 2.18 (0.13)0.6050.020.519
229Capnocytophaga sp._oral_taxon_324U− 2.28 (0.07)−2.43 (0.15)− 2.24 (0.11)− 2.25 (0.12)0.5880.030.256
230Haemophilus parahaemolyticusN− 2.29 (0.08)−1.86 (0.18)−2.23 (0.12)− 2.61 (0.11)0.002−0.11<.001*
231Porphyromonas sp._oral_taxon_278U− 2.29 (0.07)−2.40 (0.14)− 2.24 (0.11)− 2.30 (0.12)0.7160.000.977
232Selenomonas sp._oral_taxon_937U− 2.35 (0.06)−2.34 (0.12)− 2.46 (0.09)− 2.22 (0.11)0.2030.030.386
233Selenomonas dianaeN− 2.36 (0.07)− 2.52 (0.14)− 2.27 (0.10)− 2.38 (0.11)0.3670.020.569
234Selenomonas sp._oral_taxon_133U− 2.37 (0.08)− 2.25 (0.18)− 2.40 (0.11)− 2.41 (0.13)0.719−0.020.396
235Selenomonas sp._oral_taxon_478P− 2.49 (0.06)−2.54 (0.13)− 2.46 (0.09)− 2.49 (0.10)0.8820.030.306
236Capnocytophaga sp._oral_taxon_332U− 2.50 (0.07)−2.26 (0.16)− 2.42 (0.11)− 2.72 (0.11)0.043−0.100.043
237Megasphaera sp._oral_taxon_123N− 2.51 (0.08)− 2.06 (0.19)− 2.51 (0.12)− 2.77 (0.13)0.009− 0.100.002
238Bradyrhizobium elkaniiU− 2.54 (0.08)−2.37 (0.17)− 2.68 (0.11)− 2.44 (0.13)0.209−0.000.900
239Prevotella sp._oral_taxon_376P− 2.54 (0.07)−2.22 (0.17)− 2.49 (0.11)− 2.79 (0.12)0.015−0.10<.001
240Prevotella sp._oral_taxon_526P− 2.56 (0.07)−2.59 (0.14)− 2.57 (0.10)− 2.52 (0.12)0.9230.010.736
241Selenomonas sp._oral_taxon_442U− 2.58 (0.05)− 2.78 (0.11)− 2.52 (0.09)− 2.53 (0.09)0.1770.100.065
242Leptotrichia sp._oral_taxon_879U− 2.60 (0.07)− 2.56 (0.16)− 2.62 (0.10)−2.59 (0.11)0.951− 0.020.597
243Selenomonas sp._oral_taxon_149P− 2.61 (0.06)− 2.75 (0.12)− 2.70 (0.09)− 2.42 (0.10)0.0480.100.004
244Aggregatibacter sp._oral_taxon_513U− 2.66 (0.07)− 2.64 (0.14)− 2.52 (0.11)− 2.85 (0.11)0.107− 0.030.368
245Treponema vincentiiN− 2.67 (0.06)−2.55 (0.13)− 2.60 (0.09)− 2.83 (0.09)0.140−0.040.125
246Capnocytophaga sp._oral_taxon_380N− 2.70 (0.07)−2.65 (0.14)− 2.59 (0.11)− 2.88 (0.11)0.132−0.100.107
247Johnsonella sp._oral_taxon_166U− 2.78 (0.06)−2.96 (0.12)− 2.69 (0.10)− 2.80 (0.11)0.292−0.010.855
248Treponema mediumP−2.79 (0.06)− 2.85 (0.14)− 2.74 (0.10)−2.81 (0.10)0.7770.020.579
249Fretibacterium sp._oral_taxon_358U− 2.84 (0.07)−2.87 (0.14)− 2.88 (0.10)− 2.77 (0.12)0.7080.020.494
250Neisseria pharyngisN− 2.87 (0.06)−2.81 (0.13)− 2.95 (0.09)− 2.80 (0.11)0.4790.010.760
251Prevotella sp._oral_taxon_475N− 2.87 (0.06)−2.81 (0.12)− 2.84 (0.09)− 2.95 (0.09)0.575−0.040.157
252Microbacterium flavescensP− 2.89 (0.04)− 2.73 (0.09)− 2.89 (0.06)−2.97 (0.07)0.151−0.100.051
253Mitsuokella sp._oral_taxon_521N− 2.90 (0.06)−2.91 (0.12)− 2.92 (0.08)− 2.87 (0.11)0.9290.020.603
254Lactobacillus gasseriN− 2.95 (0.06)−3.08 (0.12)− 3.09 (0.09)−2.70 (0.12)0.0120.100.002
255Butyrivibrio sp._oral_taxon_080P− 2.96 (0.06)−2.85 (0.13)− 2.90 (0.09)−3.10 (0.09)0.193−0.100.038
256Fretibacterium sp._oral_taxon_361P− 2.98 (0.06)− 3.18 (0.10)− 2.97 (0.09)− 2.88 (0.11)0.2070.020.469
257Aggregatibacter actinomycetemcomitansP− 3.01 (0.07)−2.97 (0.15)−3.09 (0.10)−2.94 (0.11)0.5750.030.349
258Streptococcus sobrinusU− 3.04 (0.06)−3.21 (0.10)− 3.19 (0.09)−2.75 (0.14)0.0050.11<.001*
259GN02_[G-2] sp._oral_taxon_873P− 3.06 (0.05)−3.08 (0.12)− 3.03 (0.08)− 3.10 (0.09)0.851−0.000.927
260Prevotella multiformisN− 3.08 (0.06)− 3.12 (0.11)− 3.10 (0.09)− 3.05 (0.10)0.9010.030.359
261Brevundimonas diminutaN− 3.30 (0.04)− 3.17 (0.09)− 3.35 (0.06)− 3.30 (0.07)0.232−0.030.306
262Atopobium sp._oral_taxon_416P− 3.38 (0.05)− 3.45 (0.09)− 3.44 (0.07)− 3.27 (0.09)0.2020.100.042
263Treponema sp._oral_taxon_247P− 3.45 (0.05)− 3.35 (0.09)− 3.50 (0.07)− 3.44 (0.08)0.436− 0.020.566
264Leptothrix sp._oral_taxon_025P− 3.50 (0.04)−3.37 (0.08)− 3.53 (0.06)− 3.53 (0.06)0.216− 0.040.221
265Pyramidobacter piscolensP− 3.53 (0.04)− 3.44 (0.10)− 3.60 (0.06)−3.47 (0.07)0.251− 0.010.919
266Sphingomonas sp._oral_taxon_006P− 3.55 (0.04)−3.49 (0.08)− 3.60 (0.05)− 3.52 (0.06)0.407− 0.000.989
267Porphyrobacter tepidariusN−3.58 (0.03)−3.51 (0.08)− 3.65 (0.05)−3.54 (0.06)0.2160.010.869
  1. Rank order, OTUs are sorted high to low, with most abundant OTU at the top of the table
  2. The CLR OTU is interpreted as a log [2] fold-difference for the given species relative to the overall compositional geometric mean. A mean CLR of 3 indicates a 8-fold [23] higher abundance, and a mean CLR of − 3 indicates a 8-fold lower abundance, relative to the overall compositional geometric mean
  3. SE standard error, Pearson r the Pearson product-moment correlation coefficient
  4. p-values: bolded are significant at alpha 0.05; asterisk are significant at alpha 0.05 after Bonferroni correction
  5. Culture status: N = named; U = unnamed; P = phylotyped
  6. Socransky complex32: R = red; O = orange; P = purple; G = green; Y = yellow; B = blue; −-- = not part of the Socransky classification