Table 2 Adjusted mean difference in change from baseline in mean total DHEQ score, Schiff score and LMS scores at each time point compared to baseline (mITT population)

Week 4

5.89 (−1.018, 12.806)

0.0944

1.09 (0.940, 1.250)

< 0.0001

0.62 (0.533, 0.715)

< 0.0001

Week 8

16.99 (10.128, 23.849)

< 0.0001

1.23 (1.077, 1.383)

< 0.0001

0.71 (0.620, 0.800)

< 0.0001

Week 12

22.70 (15.870, 29.539)

< 0.0001

1.35 (1.198, 1.501)

< 0.0001

0.84 (0.753, 0.931)

< 0.0001

Week 16

27.21 (20.245, 34.165)

< 0.0001

1.40 (1.248, 1.559)

< 0.0001

0.90 (0.804, 0.986)

< 0.0001

Week 20

31.42 (24.464, 38.385)

< 0.0001

1.50 (1.349, 1.658)

< 0.0001

0.96 (0.864, 1.046)

< 0.0001

Week 24

32.55 (25.585, 39.506)

< 0.0001

1.66 (1.503, 1.812)

< 0.0001

1.09 (0.995, 1.777)

< 0.0001

LMS Intensity

LMS Duration

LMS Tolerability

LMS Description

Week 4

13.27 (9.226, 17.306)

< 0.0001

12.94 (9.111, 16.762)

< 0.0001

15.57 (12.171, 18.973)

< 0.0001

18.35 (13.850, 22.855)

< 0.0001

Week 8

17.72 (13.733, 21.704) < 0.0001

15.83 (12.054, 19.603)

< 0.0001

16.63 (13.273, 19.983)

< 0.0001

19.98 (15.536, 24.421)

< 0.0001

Week 12

20.87 (16.920, 24.829)

< 0.0001

19.07 (15.326, 22.816)

< 0.0001

20.29 (16.961, 23.619)

< 0.0001

24.32 (19.916, 28.730)

< 0.0001

Week 16

26.10 (22.051, 30.144)

< 0.0001

22.92 (19.090, 26.754)

< 0.0001

24.06 (20.652, 27.465)

< 0.0001

26.16 (21.654, 30.674)

< 0.0001

Week 20

27.74 (23.716, 31.771)

< 0.0001

25.51 (21.695, 29.323)

< 0.0001

25.55 (22.155, 28.936)

< 0.0001

28.28 (23.793, 32.771)

< 0.0001

Week 24

29.86 (25.833, 33.888)

< 0.0001

28.74 (24.930, 32.558)

< 0.0001

26.75 (23.359, 30.140)

< 0.0001

30.83 (26.341, 35.319)

< 0.0001