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Table 2 Main characteristics of included trials in vitro

From: Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and clinical research: a systematic review and meta-analysis

First author (Year)

Country

Follow up

Tooth position

CPP-ACP Group

Control Group

Outcome report

    

Sample size

Type of intervention

Frequency

Sample size

Type of intervention

Frequency

 

Zhou 2014 [15]

China

24 h

lower incisors

10

GC Tooth Mousse

tid

10

no treatment

no treatment

surface roughness (Ra, nm)

Memarpour 2015 [28]

Iran

28 d

primary canine teeth

8

GC Tooth Mousse

bid

8

no treatment

no treatment

surface roughness (Ra, nm)

Poggio 2009 [24]

Italy

36 h

upper incisors

10

GC Tooth Mousse

0, 8, 24 and 36 h

10

soft drink

0, 8, 24 and 36 h

surface roughness (Rrms, nm)

Vyavhare 2015 [29]

India

12 d

maxillary incisor teeth

6

GC Tooth Mousse

qd

6

deionized water

qd

Vickers microhardness (HV)

SoaReS 2017 [30]

India

30 d

maxillary and mandibular premolars

12

GC Tooth Mousse Plus

bid

12

no treatment

no treatment

Vickers microhardness (HV)

Rallan 2013 [31]

India

8 h

primary maxillary anterior teeth

10

GC Tooth Mousse

once

10

no treatment

no treatment

Knoop microhardness (KHN)

Carvalho 2014 [32]

Brazil

7 d

third molars

10

MI Paste Plus

qd

10

no treatment

no treatment

Knoop microhardness (KHN)

Kargul 2012 [33]

Turkey

18 h

first and second molars

15

GC Tooth Mousse

qd

15

remineralizing solutions

qd

Vickers microhardness (HV)

Memarpour 2015 [28]

Iran

28 d

primary canine teeth

10

GC Tooth Mousse

bid

10

no treatment

no treatment

Vickers microhardness (HV)

Rirattanapong 2012 [34]

Thailand

6 h

premolars

10

GC Tooth Mousse

once

10

no treatment

no treatment

Vickers microhardness (HV)

Carvalho 2013 [35]

Brazil

5 d

third molars

12

MI Paste Plus

qd

12

no treatment

no treatment

Knoop microhardness (KHN)

  1. Explanations: “qd” = “once daily,” “bid” = “twice daily,” “tid” = “three times a day,” “h” = “hour,” “d” = “day.” GC Tooth Mousse contains 10% CPP-ACP, GC Tooth Mousse Plus contains 10% CPP-ACP and 0.2% NaF, MI Paste Plus contains 10% CPP-ACP and 900 ppm fluoride