Table 1 Characteristics of the studies included in this meta-analysis
From: Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis
First author, publication year | Country | Ethnicity | Mean age, years (Case/ Control) | Age group of individuals | Genotyping method | DMFT score (Case/Control) | Polymorphisms |
|---|---|---|---|---|---|---|---|
Ouryouji, 2008 [13] | Japan | Asian | 5.4/4.8 | Children | PCR-RFLP | ≥10/0 | ENAM rs3796703 AMELX rs6639060 AMELX rs2106416 |
Azevedo, 2010 [16] | Brazil | Caucasian | 12 | Children | PCR-SSCP | ≥1/0 | LTF rs1126478 |
Kang, 2011a [17] | Korea | Asian | 21.3/23.2 | Adults | PCR | > 2/≤2 | AMELX rs17878486 |
Olszowski, 2012ab [18] | Poland | Caucasian | 5 | Children | PCR-RFLP | ≥3/< 3 | AMELX rs2106416 |
13 | Children | PCR-RFLP | ≥3/< 3 | AMELX rs2106416 | |||
Gasse, 2013 [12] | France | Caucasian | 7.6/22 | Both | PCR | ≥4/0 | AMELX rs946252 |
Jeremias, 2013a [11] | Brazil | Mixed | Case: < 6 Control: < 20 | Children | RT-PCR | ≥4/≤3 | ENAM rs1264848 ENAM rs3796704 AMELX rs946252 AMELX rs17878486 |
Ergöz, 2014 [19] | Turkey | Caucasian | 8.7/8.7 | Children | TaqMan | ≥1/0 | ENAM rs1264848 ENAM rs3796704 AMELX rs946252 AMELX rs17878486 |
Volckova, 2014 [20] | Czech | Caucasian | Range: 11–13 | Children | PCR-RFLP | ≥1/0 | LTF rs1126478 |
Gerreth, 2016 [14] | Poland | Caucasian | 2.6 | Children | RT-PCR | ≥1/0 | ENAM rs1264848 |
Yildiz, 2016a [21] | Turkey | Caucasian | Range: 20–60 | Adults | PCR-RFLP | ≥14/≤5 | AMELX rs6639060 |
Gerreth, 2017 [15] | Poland | Caucasian | Range: 1.7–3.5 | Children | TaqMan | ≥1/0 | AMELX rs17878486 |
Wang, 2017 [5] | China | Asian | 3.5/3.7 | Children | PCR | ≥4/0 | LTF rs1126478 ENAM rs3796703 |
Borilova Linhartova, 2018a [22] | Czech | Caucasian | Range: 13–15 | Children | TaqMan | ≥1/0 | ENAM rs1264848 |
Koohpeima, 2018a [23] | Iran | Caucasian | 29.8/28.4 | Adults | ARMS-PCR | NA | ENAM rs3796704 |
Wang, 2018 [24] | China | Asian | Range: 2–4 | Children | PCR | ≥8/0 | LTF rs1126478 |
Devang Divakar, 2019 [25] | Saudi Arabia | Caucasian | 6.9/23.2 | Both | RT-PCR | ≥4/0 | ENAM rs1264848 ENAM rs3796704 |