Table 1 Genotype frequencies of MMPs SNPs in Czech children according to their caries experience
From: Matrix metalloproteinases gene variants and dental caries in Czech children
MMP SNP | Genotypes | Caries-free children (dmft = 0) | Children with ECC (dmft ≥ 1) | P value | Caries-free children (DMFT = 0) | Caries-affected children (DMFT ≥ 1) | P value# | Caries-affected children (DMFT ≥ 6) | P value# |
|---|---|---|---|---|---|---|---|---|---|
|  |  | N = 52 (%) | N = 101 (%) |  | N = 155 (%) | N = 474 (%) |  | N = 111(%) |  |
MMP2 (rs2287074) | GG | 16 (30.8) | 31 (30.7) | Â | 46 (29.7) | 144 (30.4) | Â | 31 (27.9) | Â |
AG | 25 (48.0) | 56 (55.4) | 0.480 | 77 (49.7) | 236 (49.8) | 0.971 | 53 (47.7) | 0.774 | |
AA | 11 (21.2) | 14 (13.9) | Â | 32 (20.6) | 94 (19.8) | Â | 27 (24.3) | Â | |
A | 57 (54.8) | 118 (58.4) | 0.314 | 169 (54.5) | 524 (55.3) | 0.433 | 115 (51.8) | 0.298 | |
G | 47 (45.2) | 84 (41.6) | 141 (45.5) | 424 (44.7) | 107 (48.2) | ||||
MMP2 (rs243865) | CC | 28 (53.8) | 62 (61.3) | Â | 89 (57.4) | 280 (59.0) | Â | 68 (61.3) | Â |
CT | 21 (40.4) | 34 (33.7) | 0.668 | 58 (37.4) | 162 (34.2) | 0.647 | 36 (32.4) | 0.681 | |
TT | 3 (5.8) | 5 (5.0) | Â | 8 (5.2) | 32 (6.8) | Â | 7 (6.3) | Â | |
C | 77 (74.0) | 158 (78.2) | 0.248 | 236 (76.1) | 722 (76.2) | 0.523 | 172 (77.5) | 0.399 | |
T | 27 (26.0) | 44 (21.8) | 74 (23.9) | 226 (23.8) | 50 (22.5) | ||||
MMP3 (rs679620) | CC | 12 (23.1) | 24 (23.8) | Â | 37 (23.9) | 125 (26.4) | Â | 31 (27.9) | Â |
CT | 29 (55.8) | 55 (54.5) | 0.988 | 77 (49.7) | 229 (48.3) | 0.824 | 49 (44.1) | 0.642 | |
TT | 11 (21.1) | 22 (21.7) | Â | 41 (26.4) | 120 (25.3) | Â | 31 (27.9) | Â | |
C | 53 (51.0) | 103 (51.0) | 0.546 | 151 (48.7) | 479 (50.5) | 0.312 | 111 (50.0) | 0.419 | |
T | 51 (49.0) | 99 (49.0) | 159 (51.3) | 469 (49.5) | 111 (50.0) | ||||
MMP9 (rs17576) | AA | 17 (32.7) | 37 (36.6) | Â | 62 (40.0) | 198 (41.8) | Â | 51 (45.9) | Â |
AG | 29 (55.8) | 54 (53.5) | 0.873 | 74 (47.7) | 216 (45.6) | 0.894 | 53 (47.7) | 0.237 | |
GG | 6 (11.5) | 10 (9.9) | Â | 19 (12.3) | 60 (12.6) | Â | 7 (6.3) | Â | |
A | 63 (60.6) | 128 (63.4) | 0.361 | 198 (63.9) | 612 (64.6) | 0.439 | 155 (69.8) | 0.090 | |
G | 41 (39.4) | 74 (36.6) | 112 (36.1) | 336 (35.4) | 67 (30.2) | ||||
MMP13 (rs2252070) | TT | 27 (51.9) | 55 (54.5) | Â | 78 (50.3) | 215 (45.4) | Â | 50 (45.1) | Â |
CT | 19 (36.6) | 38 (37.6) | 0.762 | 64 (41.3) | 208 (43.9) | 0.485 | 47 (42.3) | 0.466 | |
CC | 6 (11.5) | 8 (7.9) | Â | 13 (8.4) | 51 (10.7) | Â | 14 (12.6) | Â | |
T | 73 (70.2) | 148 (73.3) | 0.330 | 220 (71.0) | 638 (67.3) | 0.128 | 147 (66.2) | 0.142 | |
C | 31 (29.8) | 54 (26.7) | 90 (29.0) | 310 (32.7) | 75 (33.8) | ||||
MMP16 (rs2046315) | GG | 34 (65.4) | 69 (68.3) | Â | 113 (72.9) | 353 (74.5) | Â | 74 (66.7) | Â |
AG | 15 (28.8) | 30 (29.7) | 0.458 | 36 (23.2) | 111 (23.4) | 0.481 | 33 (29.7) | 0.490 | |
AA | 3 (5.8) | 2 (2.0) | Â | 6 (3.9) | 10 (2.1) | Â | 4 (3.6) | Â | |
G | 83 (79.8) | 168 (83.2) | 0.283 | 262 (84.5) | 817 (86.2) | 0.261 | 181 (81.5) | 0.214 | |
A | 21 (20.2) | 34 (16.8) | 48 (15.5) | 131 (13.8) | 41 (18.5) | ||||
MMP16 (rs10429371) | TT | 33 (63.5) | 51 (50.5) | Â | 101 (65.2) | 306 (64.5) | Â | 63 (56.8) | Â |
CT | 13 (25.0) | 43 (42.6) | 0.090 | 44 (28.4) | 152 (32.1) | 0.203 | 39 (35.1) | 0.380 | |
CC | 6 (11.5) | 7 (6.9) | Â | 10 (6.4) | 16 (3.4) | Â | 9 (8.1) | Â | |
T | 79 (76.0) | 145 (71.8) | 0.261 | 246 (79.4) | 764 (80.6) | 0.345 | 165 (74.3) | 0.104 | |
C | 25 (24.0) | 57 (28.2) | 64 (20.6) | 184 (19.4) | 57 (25.7) | ||||
MMP20 (rs1711437) | CC | 14 (26.9) | 33 (32.7) | Â | 47 (30.3) | 157 (33.1) | Â | 44 (39.7) | Â |
CT | 27 (51.9) | 44 (43.6) | 0.610 | 79 (51.0) | 224 (47.3) | 0.717 | 53 (47.7) | 0.196 | |
TT | 11 (21.2) | 24 (23.7) | Â | 29 (18.7) | 93 (19.6) | Â | 14 (12.6) | Â | |
C | 55 (52.9) | 110 (54.5) | 0.444 | 173 (55.8) | 538 (56.8) | 0.410 | 141 (63.5) | 0.045* | |
T | 49 (47.1) | 92 (45.5) | 137 (44.2) | 410 (43.2) | 81 (36.5) | ||||
MMP20 (rs1784418) | CC | 16 (30.7) | 32 (31.7) | Â | 46 (29.7) | 148 (31.2) | Â | 42 (37.8) | Â |
CT | 24 (46.2) | 46 (45.5) | 0.993 | 84 (54.2) | 234 (49.4) | 0.521 | 54 (48.7) | 0.372 | |
TT | 12 (23.1) | 23 (22.8) | Â | 25 (16.1) | 92 (19.4) | Â | 15 (13.5) | Â | |
C | 56 (53.8) | 110 (54.5) | 0.507 | 176 (56.8) | 530 (55.9) | 0.421 | 138 (62.2) | 0.124 | |
T | 48 (46.2) | 92 (45.5) | 134 (43.2) | 418 (44.1) | 84 (37.8) |