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Table 1 In vitro studies included in the review

From: The use of PEEK in digital prosthodontics: A narrative review

Study (year)

Application

Materials tested

Outcomes

Stawarczyk et al. (2015) [20]

FDPs

CAD-CAM milled PEEK

Pressed pellet PEEK

Pressed granular PEEK (n = 15/group)

Higher mean fracture load (2.354 N) for milled FPDs than those pressed from granular PEEK (1.738 N)

Stawarczyk et al. (2013) [22]

CAD-CAM PEEK (n = 225)

Μean fracture load of 1383 N Plastic deformation starting approximately at 1200 N

Niem et al.(2019) [23]

CAD-CAM PEEK

Zirconia

Lithium disilicate glass-ceramic (n = 10/group)

PEEK exhibited

higher modulus of resilience than lithium disilicate

Comparable to that of gold alloy

Niem et al. (2019) [24]

CAD-CAM PEEK

Ceramic

Composite and

Polymer-based materials

(n = 10 /group)

Flexural strength and modulus of elasticity of PEEK not significantly influenced by thermocycling

Liebermann et al. (2016) [25]

PEEK

Hybrid material

Composite resins

PMMA-based materials (n = 40/group)

PEEK demonstrated:

The lowest solubility and water absorption

Similar hardness parameters to PMMA-based materials

Taufall et al. (2016) [26]

CAD-CAM PEEK veneered with different methods

(digital veneering, conventional veneering with crea.lign, conventional with crea.lign paste, and pre-manufactured veneers) (n = 30/group)

The digital veneering showed the

highest fracture load resistance

Cekic-Nagas et al. (2018) [27]

CAD-CAM PEEK

PMMA

Composite resin and fiber-reinforced composite materials (n = 7/group)

Highest load bearing capacity for PEEK

Wimmer et al. (2016) [28]

CAD-CAM PEEK

Nanohybrid composite

PMMA-based material

(n = 12/ group)

Significantly higher wear resistance for PEEK

Wachtel et al. (2019) [29]

IFDPs

CAD-CAM PEEK screw-retained crowns on titanium implants (n = 10)

Favorable fracture mode for PEEK compared to conventional materials

Coronal displacement of bending points

No screw loosening or veneer fracture

Sirandoni et al. (2019) [30]

CAD-CAM PEEK

PMMA

Zzirconia

Co-Cr

Ti

Highest deformation for PEEK and PMMA frameworks that decreased von Mises stresses in the frameworks, implants and abutments

PEEK exhibited critical tensile stress values in the trabecular bone

Nazari et al. (2016) [31]

CAD-CAM PEEK

Zirconia

Nickel-chromium alloy (n = 10/group)

3-unit IFDPs on two implants

Failure loads:

Zirconia 2086 ± 362 N

nickel-chromium alloy 5591 ± 1200 N

PEEK 1430 ± 262 N

Elsayed et al. (2019) [32]

CAD-CAM PEEK

Zirconia

Lithium disilicate crowns supported by titanium and zirconia implant abutments (n = 8/group)

High fracture resistance of PEEK crowns, comparable to zirconia and lithium disilicate

Jin et al. (2019) [33]

CAD-CAM PEEK and titanium frameworks veneered with composite resin n = 20/group

PEEK exhibited

Higher shear bond strength than Ti, good marginal fit and fracture resistance (1518 N)

Preis et al. (2017) [1]

CAD-CAM PEEK

Zirconia-reinforced lithium silicate ceramics

Composite resins

Zirconia

(n = 8/group)

PEEK molar implant-supported crowns showed lower fracture resistance than zirconia crowns

Total failure rate of PEEK screw-retained frameworks veneered with composite paste

Yilmaz et al. (2018) [34]

Seven different CAD-CAM HPPs 100% PEEK

80% PEEK with 20% filler

80% PEKK with 20% filler Ceramic reinforced PEEK Interlaced fiberglass and resin Fiber-composite material

New generation cubic zirconia 3Y-TZP Zirconia

Higher fracture resistance for zirconia implant-supported frameworks with cantilevers than PEEK-based materials

Ghodsi et al. (2018) [35]

CAD-CAM PEEK

Zirconia

Composite

(n = 12/group)

No clinically acceptable marginal gaps for PEEK

No significant differences observed in retention forces

Zeighami et al. (2019) [36]

CAD-CAM PEEK

Zirconia,

Composite (n = 12/group)

Better marginal adaptation for zirconia than PEEK

Chen et al. (2019) [37]

RPDs

CAD-CAM PEEK

Co-Cr

Ti alloys

PEEK caused lower stresses on periodontal ligament and higher stresses on the mucosa

Tribst et al. (2020) [38]

PEEK

Polyamide

Polyoxymethylene

Gold alloy

Titanium

CoCr

Polyoxymethylene and PEEK exhibited the lowest retentive forces

Peng et al. (2019) [39]

PEEK

CoCr alloy

No significant difference in the long-term deformation

Muhsin et al. (2018) [40]

CAD-CAM PEEK

granular PEEK

Co-Cr casting alloy

(n = 10/group)

Higher retentive force for milled PEEK clasps than thermopressed clasps

Higher retentive forces for PEEK clasps at deeper undercuts with a thicker clasp design than Co-Cr clasps after 3 years of fatigue simulation

Negm et al. (2019) [41]

CAD-CAM Milled PEEK Thermo-pressed PEEK (n = 10/group)

Higher fit and trueness for directly milled frameworks

Arnold et al. (2018) [42]

CAD-CAM Milled PEEK

Cast metal frameworks with different techniques (n = 12/group)

PEEK RPD frameworks have better precision and fit than metal frameworks fabricated using different techniques

Hada et al. (2020) [43]

Complete denture framework

PEEK

Fiber-reinforced composite

Nano-zirconia

cobalt-chromium-molybdenum alloy (n = 6group)

PEEK provides lower reinforcement than the other materials

Emera et al. (2019) [5]

Double-crown-retained Removable Dental Prostheses

Zirconia or PEEK primary crowns

Zirconia or PEEK secondary crowns

Telescopic attachments fabricated from zirconia primary crowns and PEEK secondary crowns exhibited the lowest stresses transmitted to the implants

Schubert et al. (2019) [44]

Implant-supported zirconia primary crowns with

electroformed secondary crowns or CAD-CAM PEEK secondary crowns (n = 10/group)

Stable retentive force values over 10 years of simulated aging for PEEK secondary crowns

Merk et al. (2016) [45]

Zirconia primary crowns

Secondary PEEK crowns of different taper and manufacturing methods;

milled from PEEK blanks; thermo-pressed from PEEK pellets;

thermo-pressed from granular PEEK (n = 10/group)

Fabrication method and taper angle had no consistent effect on retentive forces within different groups

Stock et al. (2016) [46]

Zirconia primary crowns

Secondary PEEK crowns of different taper and manufacturing methods;

milled from PEEK blanks; thermo-pressed from PEEK pellets;

thermo-pressed from granular PEEK (n = 30/group)

Milled 0° tapered PEEK crowns presented the lowest retention force

Milled 2° tapered PEEK crowns had the highest retention force values

Retention force of pressed PEEK not influenced by the taper angle

Decrease of retention after the first twenty pull-off cyclew for pressed PEEK

Wagner et al. (2018) [47]

PEEK telescopic crowns and cobalt chrome copings of different taper and manufacturing methods (n = 10/group)

Stable retention load values for each test group

Stock et al. (2016) [48]

Milled PEEK primary and cobalt-chromium (CoCr), zirconia (ZrO2) and galvanic

(GAL) secondary crowns with three different tapers (n = 30, 10/taper)

Milled PEEK can be used as primary crown material with high retentive forces in combination with secondary zirconia, cobalt-chromium or electroformed crowns

Benli et al. (2020) [11]

Occlusal splint

CAD-CAM PEEK

Vinyl acetate

Polymethyl methacrylate

Polycarbonate

Polyethyleneterephthalate

(n = 12/group)

After chewing simulation PEEK occlusal splints exhibited lower loss of volume and lower roughness alteration compared to other CAD-CAM materials

Benli et al. (2020) [49]

Intra-radicular posts

Milled PEEK

Glass-fiber

Cast-metal

(n = 20/group)

PEEK posts exhibited the highest tensile bond strength and the lowest surface roughness

Kaleli et al. (2018) [9]

Implant abutments

PEEK and zirconia customized abutments

Finite element analysis showed higher stress values in restorative crowns for PEEK abutments

Abdullah et al. (2016) [50]

Provisional crowns

PEEK

VITA CAD Temp

Telio CAD-Temp

Protemp 4

PEEK demonstrated superior fit and fracture strength than other materials