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Table 2 Clinical studies included in the review

From: The use of PEEK in digital prosthodontics: A narrative review

Study (Year) Study design Intervention Outcome
Parmigiani-Izquierdo et al. (2017) [51] Case report Zirconia implants restored with milled PEEK frameworks veneered with composite resin for the replacement of upper molars Cushioning of occlusal loads while chewing
Viable solution for patients with intolerance to metal alloys
Cabello-Dominguez et al. (2019) [52] Case report Monolithic zirconia fixed prosthesis in the maxilla and PEEK framework with gingival composite resin combined with lithium disilicate crowns in the mandible for the rehabilitation of a completely edentulous patient The reduced weight and modulus of elasticity of PEEK could reduce the risk of mechanical complications
Higher cost than metal-ceramic or metal-acrylic restoration
Zoidis (2018) [4] Case report PEEK implant framework material in combination with prefabricated
PMMA veneers for the fabrication of a complete maxillary arch implant-supported fixed restoration
Esthetic outcome comparable with that of ceramic restoration
After 2 years, no sign of screw loosening,
veneering material chipping, wear, or staining
Harb et al. (2019) [53] Case report Milled PEEK framework combined with acrylic resin denture teeth and heat-cured acrylic resin denture for Kennedy Class I RPD fabrication Adequate fit and good patient satisfaction in terms of function and esthetics
Costa-Palau et al. (2014) [54] Case report Milled PEEK framework for the fabrication of a maxillary obturator prosthesis Compared to conventional obturators
PEEK frameworks permit the fabrication of lighter prostheses with improved retention, function and esthetics
Mangano et al. (2019) [55] Clinical study Combining Intraoral and Face Scans for the Design and Fabrication of
CAD-CAM PEEK Implant-Supported Bars for Maxillary Overdentures (15 patients)
After a year in function
100% implant survival
80% success rate
Spies et al. (2018) [56] Case report Implant-supported overdenture with the receptor part of the bar milled from PEEK polymerized into a zirconia framework for the rehabitation of an edentulous patient High patient satisfaction with function and esthetics after 6 months
Hahnel et al. (2018) [57] Case report Primary CoCr copings and secondary CAD-CAM PEEK framework veneered with composite resin for the fabrication of double-crown-retained interim removable dental prosthesis Biocompatibilityand low weight
no complications after 3 months
Siewert (2018) [58] Case report Primary zirconia copings and secondary PEEK framework veneered with monolithic zirconia for the rehabilitation of an edentulous patient with intolerance to titanium High chewing comfort
Dampening of chewing forces
Beretta et al. (2019) [10] Randomized clinical trial Comparison of CAD-CAM fabricated customized healing abutments and standard healing caps placed at the surgical stage for the creation of the desired emergence profile (n = 10/group) After a healing period of 1–3 months
Patients with PEEK customized healing abutments showed higher functional implant prosthodontics score (FIPS) and lower numerical rating scale (NRS) values