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Table 2 Clinical studies included in the review

From: The use of PEEK in digital prosthodontics: A narrative review

Study (Year)

Study design

Intervention

Outcome

Parmigiani-Izquierdo et al. (2017) [51]

Case report

Zirconia implants restored with milled PEEK frameworks veneered with composite resin for the replacement of upper molars

Cushioning of occlusal loads while chewing

Viable solution for patients with intolerance to metal alloys

Cabello-Dominguez et al. (2019) [52]

Case report

Monolithic zirconia fixed prosthesis in the maxilla and PEEK framework with gingival composite resin combined with lithium disilicate crowns in the mandible for the rehabilitation of a completely edentulous patient

The reduced weight and modulus of elasticity of PEEK could reduce the risk of mechanical complications

Higher cost than metal-ceramic or metal-acrylic restoration

Zoidis (2018) [4]

Case report

PEEK implant framework material in combination with prefabricated

PMMA veneers for the fabrication of a complete maxillary arch implant-supported fixed restoration

Esthetic outcome comparable with that of ceramic restoration

After 2 years, no sign of screw loosening,

veneering material chipping, wear, or staining

Harb et al. (2019) [53]

Case report

Milled PEEK framework combined with acrylic resin denture teeth and heat-cured acrylic resin denture for Kennedy Class I RPD fabrication

Adequate fit and good patient satisfaction in terms of function and esthetics

Costa-Palau et al. (2014) [54]

Case report

Milled PEEK framework for the fabrication of a maxillary obturator prosthesis

Compared to conventional obturators

PEEK frameworks permit the fabrication of lighter prostheses with improved retention, function and esthetics

Mangano et al. (2019) [55]

Clinical study

Combining Intraoral and Face Scans for the Design and Fabrication of

CAD-CAM PEEK Implant-Supported Bars for Maxillary Overdentures (15 patients)

After a year in function

100% implant survival

80% success rate

Spies et al. (2018) [56]

Case report

Implant-supported overdenture with the receptor part of the bar milled from PEEK polymerized into a zirconia framework for the rehabitation of an edentulous patient

High patient satisfaction with function and esthetics after 6 months

Hahnel et al. (2018) [57]

Case report

Primary CoCr copings and secondary CAD-CAM PEEK framework veneered with composite resin for the fabrication of double-crown-retained interim removable dental prosthesis

Biocompatibilityand low weight

no complications after 3 months

Siewert (2018) [58]

Case report

Primary zirconia copings and secondary PEEK framework veneered with monolithic zirconia for the rehabilitation of an edentulous patient with intolerance to titanium

High chewing comfort

Dampening of chewing forces

Beretta et al. (2019) [10]

Randomized clinical trial

Comparison of CAD-CAM fabricated customized healing abutments and standard healing caps placed at the surgical stage for the creation of the desired emergence profile (n = 10/group)

After a healing period of 1–3 months

Patients with PEEK customized healing abutments showed higher functional implant prosthodontics score (FIPS) and lower numerical rating scale (NRS) values