Fig. 4

Protein interaction networks of proteins that significantly changed in abundance, determined using STRING version 11.0. A total of 13 proteins were analysed. Seven additional proteins were added to determine protein interactions during orthodontic treatment. Each protein was represented with a node and its respective gene name. The colours of the node representations are as follows: red, positive regulation of biological process; dark green, response to stimulus; purple, metabolic process; dark blue, cellular process; light green, immune system process; and yellow, regulation of localisation. Meanwhile, interactions of proteins were identified using the edges connecting the nodes. The thickness of the edge is represented as follows: thinnest, low confidence (interaction score: 0.150); thin, medium confidence (interaction score: 0.400); thick, high confidence (interaction score: 0.700); and thickest, highest confidence (interaction score: 0.900)