Table 3 Top 10 hub genes with higher degrees of PPI network of pulpitis
Gene symbol | Description | Function | Degree |
|---|---|---|---|
PTPRC | Receptor-type tyrosine-protein phosphatase C | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. | 126 |
TLR8 | Toll-like receptor 8 | Key component of innate and adaptive immunity | 100 |
CD86 | T-lymphocyte activation antigen CD86 | Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. | 100 |
IL6 | Interleukin-6 | Cytokine with a wide variety of biological functions. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. | 135 |
CCL2 | C-C motif chemokine 2 | Chemotactic factor that attracts monocytes and basophils | 80 |
MMP9 | Matrix metalloproteinase-9 | May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration | 83 |
IL8 | Interleukin-8 | A chemotactic factor that attracts neutrophils, basophils, and T-cells, major mediator of the inflammatory response | 101 |
SPI1 | Spi-1 Proto-Oncogene | This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. | 76 |
ICAM1 | Intercellular adhesion molecule 1 | Encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system | 83 |
LCP2 | Lymphocyte cytosolic protein 2 | Involved in T-cell antigen receptor mediated signalling | 77 |