Preemptive intravenous iron therapy versus autologous whole blood therapy for early postoperative hemoglobin level in patients undergoing bimaxillary orthognathic surgery: a prospective randomized noninferiority trial

Table 3 Comparison of perioperative changes in hemoglobin, iron, and ferritin levels based on the values at 4 weeks before surgery (baseline) between the two groups

Group	Intravenous iron	Autologous whole blood	p
n	32	32	p
Change of hemoglobin level (%)
Immediately before surgery	− 6.47 ± 5.51	− 16.36 ± 10.27	< 0.001
Postoperative day 1	− 29.92 ± 11.21	− 29.73 ± 8.38	0.938
Postoperative day 2	− 37.18 ± 10.07	− 30.64 ± 7.02	0.004
Change of iron level (%)
Immediately before surgery	− 14.78 ± 39.97	− 35.95 ± 54.82	0.082
Postoperative day 1	− 65.9 ± 23.04	− 76.26 ± 15.57	0.04
Postoperative day 2	− 43.57 ± 33.42	− 56.27 ± 35.9	0.148
Change of ferritin level (%)
Immediately before surgery	273.28 ± 324.54	− 20.53 ± 213.09	< 0.001
Postoperative day 1	261.35 ± 281.57	45.38 ± 195.97	0.001
Postoperative day 2	309.07 ± 344.98	53.55 ± 188.3	0.001

Values are expressed as mean ± SD
Changes (%) are defined as ((each value—value at 4 weeks before surgery)/value at 4 weeks before surgery) × 100

ISSN: 1472-6831