Association between 20q12 rs13041247 polymorphism and risk of nonsyndromic cleft lip with or without cleft palate: a meta-analysis

Table 3 Summary results of the association between polymorphism and NSCL/P risk in the meta-analysis

Subgroup	Ethnicity	Genotype	No of studies	Test of association				Test of heterogeneity
Subgroup	Ethnicity	Genotype	No of studies	OR(95%CI)	Z-test	P-value	Model	P-value	I² (%)
rs13041247	East Asian	C vs T	8	0.847 (0.702–1.021)	1.74	0.082	R	0.000	87.2%
		CC vs CT	8	0.837 (0.657–1.067)	1.43	0.151	R	0.001	72%
		CC vs TT	8	0.725 (0.494–1.063)	1.65	0.100	R	0.000	86.8%
		CC + CT vs TT	8	0.805 (0.630–1.029)	1.73	0.083	R	0.000	82.3%
		CT + TT vs CC	8	1.265 (0.951–1.684)	1.61	0.106	R	0.000	82.1%
rs13041247	Caucasian	C vs T	2	0.936 (0.786–1.114)	0.75	0.454	F	0.358	0.0%
		CC vs CT	2	1.197 (0.816–1.757)	0.92	0.358	F	0.193	41.0%
		CC vs TT	2	0.988 (0.674–1.446)	0.06	0.949	F	0.237	28.4%
		CC + CT vs TT	2	0.855 (0.677–1.081)	1.31	0.191	F	0.756	0.0%
		CT + TT vs CC	2	0.918 (0.835–1.056)	0.47	0.641	F	0.187	42.6%
rs13041247	Overall	C vs T	13	0.874 (0.764–0.999)	1.98	0.048	R	0.000	80.2%
		CC vs CT	13	0.904 (0.733–1.114)	0.98	0.325	R	0.000	69.8%
		CC vs TT	13	0.767 (0.570–1.034)	1.74	0.082	R	0.000	81.4%
		CT vs TT	13	0.839 (0.734–0.959)	2.57	0.010	R	0.0303	50.8%
		CC + CT vs TT	13	0.824 (0.701–0.968)	2.35	0.019	R	0.000	69.7%
		CT + TT vs CC	13	1.185 (0.934–1.503)	1.40	0.162	R	0.000	77.9%

Abbreviations: C vs T, the allele model; CC vs CT, the heterozygote model; CC vs TT, the homozygote model;CC + CT vs TT, the recessive model; CT + TT vs CC, the dominant model; I², I-squared; R, the random effect model; F, the fixed effect model

ISSN: 1472-6831