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Table 1 Characteristics of the included studies in this review

From: Scoping review of trials evaluating adhesive strategies in pediatric dentistry: where do simplified strategies lie?

Study Study type Participants Age range Intervention   Sample size   Observation period (months) Criteria Outcomes Conclusion
Cavalheiro et al. [26] RCT 62 5–8 year olds
Mean: 7.1
1. Adper Single Bond (15 s etching)
2. Adper Single Bond 2 (7 s etching) (3M ESPE)
  100 Class I restorations
1. n = 50
2. n = 50
  18 months FDI Survival rates were as follows:
15 s etching = 78.3%
7 s etching = 92%
The etching time did not influence the outcome of the restorations, although a reduced time showed better tendency
Yazicioglu et al. [27] RCT 31 4–9 years old
Mean: 6.67
1. Vertise flow (Kerr)
2. Clearfil SE Bond and Filtek Z250 (Kuraray; 3M ESPE)
  61 Class I restorations
1. n = 30
2. n = 31
  12 months Modified
USPHS
No loss of retention was documented for either materials for a 1-year period Good clinical scores for the self-adhesive material after 1-year. No differences for both materials
Gianetti et al. [28] Clinical trial 28 6–12 years old
Mean 8.5 years
1. Filtek Z250
(3M ESPE)
2. SDR Flowable (Dentsply)
  56 Class II restorations
1. (n = 28)
2. (n = 28)
  24months Modified
USPHS
Retention rates were not reported. However, marginal adaptation seems to be favoured in the SDR composite system The authors recommend the use of SDR, a novel flowable resin for primary teeth due to its ease of application and results at 2 years time
Oter et al. [29] RCT 80 Mean: 7.4 years 1. Filtek Z250
(3M ESPE)
2. Filtek Bulkfill
(3M ESPE)
Adhesive: Single Bond Universal (self-etch mode)
  160 Class I restorations
1. (n = 80)
2. (n = 80)
  12 months Modified
USPHS
All of the evaluated restorations were retained after 12 months (100% success rate) Both materials were clinically successful after 1 year
Lenzi et al. [30] RCT 44 5–10 years old
Mean: 7.2 years
1. Scotchbond Universal (E&R)
2. Scotchbond Universal (SE) (3M ESPE)
  90 Class I/II restorations
1. (n = 87)
2. (n = 88)
  18 months Modified
USPHS
Survival rates were 100 percent until 6 months, 90.6% at 12 months and 81.4% at 18 months The different strategies had not influence on the clinical behaviour after selective caries removal
Sabbagh et al. [31] RCT 34 6–12 years old 1. Vertise Flow (Kerr)
2. Premise Flowable + Optibond All-In-One (self-etch)
  68 Class I restorations
1. (n = 34)
2. (n = 34)
  24 months Modified
USPHS
No significant difference of outcomes was found between Vertise Flow and Premise Flowable
At a 2-year re-call, 3 VF restorations were lost, and 1 PF restoration
Vertise Flow showed a similar clinical behaviour to Premise Flowable at a 2-year observation period
Atabek et al. [32] RCT 30 7–16 years old 1. Herculite Ultra (Kerr)
2. SonicFill (Kerr)
Adhesive: Optibond-All-In-One (Kerr)
  60 Class I restorations
1. (n = 30)
2. (n = 30)
  24 months Modified
USPHS
Both intervention groups resulted in 100% retention, anatomical form and secondary caries categories Both materials demonstrated similar clinical behaviour results at 2 years. The easier placement technique of sonic fill may be of benefit in children
Donmez et al. [33] RCT 32 4–7 years old
Mean: 5.96
1. Optibond FL (Kerr)
2. XP Bond (Dentsply)
3: AdheSE (Ivoclar)
4: G-bond
(GC Corporation)
  128 Class II restorations
1. (n = 32)
2. (n = 32)
3: (n = 32)
4: (n = 32)
  36 months FDI The failure rates of the 4 groups were as follows, at 36 months:
G1: 3.8%
G2: 4.2%
G3: 7.4%
G4: 7.7%
There were no significant differences in retention rate of the different adhesives, but there were marginal adaptation differences, with E&R systems outperforming SE systems