Table 2 Characteristics of studies included for the systematic review and meta-analysis

Case report (n = 9)

Cizza and Migues [57]

III

S

1

Mx 2.3

6/12

DPG‡

Harris [25]

SCTG

Deliberador et al. [35]

III

S

1

Md 3.1

12

LPF + TT†

Deliberador et al. [35]

SCTG

Gajendran and Parthasarathy [58]

III

M

2

Md 3.1, 4.1

12

GUT†

Allen and Cohen [28]

FGG

Luthra et al. [59]

III

M

2

Mx 2.3/2.4

6/12

CAF‡

Allen [23]

Periosteal pedicle graft + Autogenous bone

Moussa and Bissada [60]

III

M

6

Mx 1.5/1.3/1.2/ 1.1

12

TT†

Allen [34]

ADM

Mx 2.4/ 2.6

MCAF†

Zucchelli et al. [33]

SCTG

Rath et al. [61]

III

S

1

Md 4.1

6

2SP (FGG/CAF)‡

Bernimoulin et al. [18]

FGG/BB (BioMed®)

Rath et al. [62]

III

S

1

Md 4.1

6

FGG‡

Holbrook and Ochsenbein [19]

FGG

Ribeiro et al. [31]

III

S

1

Mx 2.4

36

TT†

Ribeiro et al. [31]

SCTG

Zuchelli and De Sanctis [38]

III

S

1

Md 3.6

12/60

M2SP (FGG/LMCAF)†

Zuchelli and De Santics [38]

FGG/No

Case series (n = 17)

Boltchi et al. [43]

I, II,III

S or M

14

NR

6

CAF‡

Allen [23]

BB (Guidor®)

Carnio et al. [44]

II, III

S

2

Mx/Md 1.3/2.3

6/12

DPG‡

Nelson [22]

SCTG

Cosgarea et al. [45]

I, II, III

M

25

Mx/Md incisors, canines or premolars

12

MCAT†

Aroca et al. [6]

ADM (Mucoderm®)

Garg et al. [46]

I and III M

9

Mx incisor, canines and premolar

6

VISTA†

Zadeh [37]

BB (PRF) /No

Gupta et al. [47]

I, II,III

S or M

7

Md incisors

9

BFP‡

Marggraf [21]

No

Jepsen et al. [48]

I,II,III

S

8

Mx/Md 1.3/ 2.3/ 3.3

12

CAF‡

Allen [23]

BB (Atrisorb®)

Case series (n = 17)

Lee et al. [39]

Only III S

2

Md 4.3

6/36

MLPF†

Lee et al. [39]

SCTG

Nart et al. [49]

II and III

S or M

7

Md incisors

11.70 (6.21)

CAF‡

Zucchelli and De Sanctis [27]

SCTG

Nart and Valles [50]

II and III

S

7

Md incisors

20.53 (8.89)

TT†

Tözüm and Dini [29]

SCTG

Núñez et al. [40]

II and III

S

7

Md 3.1, 4.1

12

2SSA (Odontoplasty/TT)†

Núñez et al. [40]

SCTG

Pini Prato et al. [51]

I and III,

S

25

Mx/Md incisors, canines or premolars

12/ 240

CAF‡

Allen and Miller [24]

No

Romanos et al. [52]

I, II and III

M

48

Mx/Md

12

MCAT†

Aroca et al. [6]

ADM (Alloderm®)

Sato et al. [53]

Only III M

4

Md central incisors

12/24

PCTG‡

Ito et al. [26]

SCTG + EMD

Sculean et al. [54]

I, II and III M

5

Mx

12

MCAT†

Aroca et al. [6]

SCTG + EMD

Sculean et al. [55]

I and III

S or M

7

Mx

12

MCAT†

Aroca et al. [6]

SCTG

Sculean and Allen [41]

I, II and III S

10

Md incisors and canines

12

LCT†

Sculean and Allen [41]

SCTG + EMD

Yaman et al. [56]

Only III M

68

Mx/Md

12

MCAT†

Aroca et al. [6]

SCTG

Clinical trials (n = 7)

Aroca et al. [6]

Only III M

139

Mx/Md

6/12

MCAT†

Aroca et al. [6]

SCTG/ + or—EMD

Cairo et al. [7]

Only RT2 S

29

Mx incisors, canines and premolars

6

CAF‡

Allen and Miller [24]

SCTG/ No

Cueva et al. [14]

I, II and III S or M

7

Mx/Md incisors, canines and premolars

6

CAF‡

Allen and Miller [24]

EMD/No

Mercado et al. [42]

III and IV M

127

Md incisors and canines

36

CAF†

Mercado et al. [42]

SCTG/ + or—EMD

Ozcelik et al. [63]

I, II and III S

30

Mx/ Md incisors and canines

6

MLPF†

Chambrone and Chambrone [32]

No

Ozcelik et al. [65]

RT1 and RT2

S

62

Mx/Md incisors and canines

6

CAF‡

Allen and Miller [24]

SCTG

Ucak et al. [64]

Only III

S

50

Mx/Md incisors and canines

6

LMCAF†

Zucchelli et al. [30]

No

Restrospective studies (n = 4)

César-Neto et al. [66]

II and III

S

3

Mx/Md incisors, canines and premolars

6

CAF‡

Langer and Langer [20]

SCTG

4

DPG/LPF‡

Harris [25]/Grupe and Warren [17]

Chao [36]

I, II and III S or M

36

Mx/Md

15 (5.2)

PST†

Chao [36]

BB (Bio-Gide®)/ADM (Alloderm®)

Esteibar et al. [67]

Only III, S or M

121

Mx/Md

12

FGG‡

Holbrook and Ochsenbein [19]

FGG

CAF‡

Langer and Langer [20]

SCTG

DPG‡

Harris [25]

Gil et al. [68]

I, II and III M

54

Mx/Md

 ≥ 12 (14.6 (4.6))

VISTA†

Zadeh [37]

SCTG/ADM (Perioderm®) /XCM (Mucograft®) + PDGF (GEM21S®)