Factors influencing an eruption of teeth associated with a dentigerous cyst: a systematic review and meta-analysis

Table 6 GRADE summary of findings

Admission type	No. of studies	Study design	Risk of bias	Inconsistency	Indirectness	Imprecision	Other considerations	RR (95% CI)	Certainty
Certainty assessment
RR (risk ratio) for spontaneous eruption of the teeth	4	Retrospective cohort studies	Serious	Serious^a	Not serious	Serious^b	None	2.608	Very low
D (mean difference) for mean age	4	Retrospective cohort studies	Serious	Serious^a	Not serious	Serious^b	None	NR	Very low
RR (risk ratio for root formation)	3	Retrospective cohort studies	Serious	Serious^a	Not serious	Serious^b	None	2.106	Very low
D (mean difference) for cusp depth	3	Retrospective cohort studies	Serious	Serious^a	Not serious	Serious^b	None	NR	Very low
D (mean difference) for angulation	4	Retrospective cohort studies	Serious	Serious^a	Not serious	Serious^b	None	NR	Very low
D (mean difference) for cyst area	2	Retrospective cohort studies	Serious	Serious^a	Not serious	Serious^b	None	NR	Very low
D (mean difference) for space/tooth size	4	Retrospective cohort studies	Serious	Serious^a	Not serious	Serious^b	None	NR	Very low

GRADE, Grading of Recommendations Assessment, Development, and Evaluation; RR, risk ratio; CI, confidence level; NR, not reported
^aDifferent sample sizes and timings of studies lead to inconsistency in the results
^bVery few studies published which raises the suspicion of publication bias
GRADE quality of evidence: High quality: We are very confident that the true effect lies close to that of the estimate of the effect. Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low quality: Our confidence in the effect estimate is limited. The true effect may be substantially different from the estimate of the effect. Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect

ISSN: 1472-6831