Fig. 3
From: Specialized pro-resolving lipid mediators in endodontics: a narrative review
SPM delivery system strategy for endodontic applications. SPMs can be used as therapeutic agents for innovative clinical endodontic therapy for pulpitis or apical periodontitis. To improve SPM efficacy and stability, SPM encapsulation may be required, and different formulations and designs are under investigation (microspheres, fibers or hydrogels) to create new therapeutic devices. Before they can be used in humans, these SPM delivery systems must be characterized and assessed in vitro and in vivo (injectability, physical characterization, efficiency evaluation and animal model assessments) to validate that they fulfill clinical specifications. The clinical objectives are to use these SPM delivery systems for vital pulp therapy or in pulp tissue engineering