From: Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients
Clinical criteria |
Multifocal symmetric distribution |
White and red lesions exhibiting one or more of the following forms: |
Reticular/papular |
Atrophic (erythematous) |
Erosive (ulcerative) |
Plaque |
Bullous |
Lesions are not localized exclusively to the sites of smokeless tobacco placement |
Lesions are not localized exclusively adjacent to and in contact with dental restorations |
Lesions onset does not correlate with the start of a medication |
Lesions onset does not correlate with the use of cinnamon-containing products |
Histopathological criteria |
Band-like or patchy, predominately lymphocytic infiltrate in the lamina propria confined to the epithelium-lamina propria interface |
Basal cell liquefactive (hydropic) degeneration |
Lymphocytic exocytosis |
Absence of epithelial dysplasia |
Absence of verrucous epithelial architectural change |