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Table 3 Radioactivity of 14C-lidocaine in the serum

From: Effect of epinephrine on the absorption of lidocaine following application to the oral mucosa in rats

  Lidocaine
Mean ± SD
Lidocaine with epinephrine
Mean ± SD
p value
Sample size 12 12  
Time (min)    
 0.5 19.1 ± 9.2 15.6 ± 6.7 0.291
 2 21.8 ± 10.4 24.8 ± 5.6 0.383
 5 34.1 ± 9.5 30.7 ± 6.6 0.322
 10 55.9 ± 4.3 40.9 ± 4.8 < 0.001
 20 76.9 ± 8.2 48.4 ± 8.6 < 0.001
 30 63.4 ± 7.8 59.8 ± 4.7 0.189
 40 49.3 ± 5.7 70.2 ± 4.4 < 0.001
 50 34.8 ± 7.3 88.2 ± 2.9 < 0.001
 60 20.6 ± 9.5 81.0 ± 4.8 < 0.001
  1. Data presented as the mean of 14C radioactivity in dpm/1 mL serum
  2. p value compares lidocaine versus lidocaine with epinephrine
  3. Unpaired t-test used to compare means
  4. SD standard deviation