Fig. 6

The result of WGCNA analysis. A Sample clustering to detect outliers; B Analysis of network topology for a set of soft‐thresholding powers. Scale independence and mean connectivity of various soft-thresholding values (β). The left picture displays the scale free fit index (y‐axis) as a function of the soft‐thresholding power (x‐axis). The right picture shows the mean connectivity (degree, y‐axis) as a function of the soft‐ thresholding power (x‐axis); C clustering dendrograms of genes, with dissimilarity based on topological overlap, together with assigned module colors. Cluster dendrogram of all filtered genes enriched based on the dissimilarity measure and the cluster module colors; D the heatmap plot describes the Topological Overlap Matrix (TOM) among DEGs in the analysis; E The eigengene dendrogram and heatmap identify groups of correlated eigengenes termed meta modules