Table 3 Comparison of quantitative outcome variables in relation to the smoking type over 4 time points of study follow-up period

KTW

(mm)

1.7

(0.9)

1.9

(1.4)

1.9

(1.1)

1.7

(.9)

1.9

(1.4)

1.9

(1.1)

1.8

(1.1)

1.7

(1.3)

1.9

(1.1)

1.7

(0.9)

1.9

(1.4)

1.9

(1.1)

F-value; p value

Time period: 0.006; 0.941 smoking type: 0.207; 0.814

PD

(mm)

6.9

(0.9)

6.3

(1.4)

6.5

(1.3)

4.4

(.5)

4.7

(.5)

4.2

(0.6)

4.7

(0.6)

5.5

(1.1)

4.5

(0.8)

4.8

(0.9)

5.6

(1.1)

4.4

(0.8)

F-value; p value

Time period: 39.98; p < 0.0001 smoking type: 2.53; p = 0.024*

MMP8

(pg/ng)

20.1

(6.3)

27.1

(5.3)

9.4

(4.3)

10.1

(1.6)

11.4

(1.8)

3.3

(0.8)

14.9

(16.3)

22.9

(35.2)

5.2

(4.6)

12.2

(5.6)

16.9

(7.9)

4.1

(2.2)

F-value; p value

Time period: 8.52; p < 0.0001 smoking type: 0.78; p = 0.583

IL6

(pg/ng)

153.7

(20.6)

183

(8.4)

47.2

(3.7)

63.2

(11.3)

85.6

(6.4)

15.6

(2.3)

65.4

(15.6)

96.3

(34.5)

18.6

(10.6)

80.6

(43.3)

120.6

(50)

19.4

(11.1)

F-value; p value

Time period: 127.82; p = 0.0001 smoking type: 10.86; p = 0.0001*

IL1 β

(pg/ng)

3.55

(0.06)

3.62

(0.08)

2.84

(0.04)

1.96

(0.10)

2.14

(0.11)

1.28

(0.17)

2.01

(0.09)

2.44

(0.44)

1.32

(0.19)

2.30

(0.62)

2.84

(0.75)

1.47

(0.49)

F-value; p-value

Time period: 168.95; p < 0.0001 Time period smoking type: 26.38; p < 0.0001*

TIMP-1

4.61

(3.4)

1.8

(2.4)

6.9

(2.0)

25.6

(16.8)

14.2

(4.8)

49.8

(19.6)

10.6

(5.4)

5.9

(4.1)

42.3

(25.6)

10.1

(5.8)

5.7

(4.1)

43.6

(24.4)

(pg/ng)

F-value; p value

Time period: 42.44; p < 0.0001 smoking type: 10.12, p < 0.0001*