From: Polymorphic variants in genes related to stress coping are associated with the awake bruxism
BDNF c.196G > A (rs6265) | |||||
---|---|---|---|---|---|
Genotype frequencies (%) | Allele frequencies (%) | ||||
GG n (%) |
GA n (%) |
AA n (%) |
G n (%) |
A n (%) | |
Patients with bruxism (AB) n = 104 | 47 (45.1%) | 55 (52.9%) | 2 (2.0%) | 146 (71.6%) | 58 (28.4%) |
Males (n = 26) | 16 (61.5%) | 9 (34.6%) | 1 (3.9%) | 41 (78.9%) | 11 (21.1%) |
Females (n = 78) | 31 (39.7%) | 46 (59.0%) | 1 (1.3%) | 108 (69.2%) | 48 (30.8%) |
Control group (C) (n = 193) | 116 (60.2%) | 67 (34.7%) | 10 (5.1%) |
299 (77.5%) *1000Genomes: 80.0% |
87 (22.5%) *1000Genomes: 20.0% |
Control males (n = 97) | 63 (65.0%) | 29 (29.9%) | 5 (5.1%) | 155 (79.9%) | 39 (20.1%) |
Control females (n = 96) | 53 (55.2%) | 38 (39.6%) | 5 (5.2%) | 144 (75.0%) | 48 (25.0%) |
Comparisons of allelic and genotypic frequencies between groups under the study | |||||
[GG + GA]vs[AA] | [GG]vs[GA + AA] | [GG]vs[AA] | [G]vs[A] | [A]vs[G] | |
AB** versus C OR, 95% CI P value |
OR = 0.36 [0.08–1.67] P = 0.174 |
OR = 0.55 [0.34–0.89] P = 0.014 |
OR = 2.03 [0.43–9.60] P = 0.365 |
OR = 0.735 [0.50–1.08] P = 0.116 |
OR = 1.36 [0.93–2.00] P = 0.116 |
AB males versus C males OR, 95% CI P value |
OR = 0.74 [0.08–6.59] P = 0.783 |
OR = 0.86 [0.35–2.11] P = 0.747 |
OR = 1.27 [0.14–11.65] P = 0.832 |
OR = 0.94 [0.44–1.99] P = 0.867 |
OR = 1.07 [0.50–2.26] P = 0.867 |
AB females** versus C females OR, 95% CI P value |
OR = 0.27 [0.03–2.07] P = 0.158 |
OR = 0.54 [0.29–0.98] P = 0.042 |
OR = 2.93 [0.33–26.19] P = 0.317 |
OR = 0.75 [0.47–1.20] P = 0.231 |
OR = 1.33 [0.83–2.14] P = 0.231 |
AB females** versus AB males OR, 95% CI P value |
OR = 0.33 [0.02–5.38] P = 0.410 |
OR = 0.41 [0.17–1.03] P = 0.053 |
OR = 1.93 [0.11–33.05] P = 0.642 |
OR = 0.60 [0.29–1.28] P = 0.183 |
OR = 1.66 [0.79–3.50] P = 0.183 |
C females versus C males OR, 95% CI P value |
OR = 1.01 [0.28–3.61] P = 0.987 |
OR = 0.67 [0.37–1.19] P = 0.167 |
OR = 0.84 [0.23–3.06] P = 0.793 |
OR = 0.76 [0.47–1.22] P = 0.250 |
OR = 1.33 [0.82–2.14] P = 0.250 |