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Table 2 Alleles and genotypes frequencies for BDNF c.196G > A (rs6265) polymorphism in studied groups

From: Polymorphic variants in genes related to stress coping are associated with the awake bruxism

  BDNF c.196G > A (rs6265)
Genotype frequencies (%) Allele frequencies (%)
GG
n (%)
GA
n (%)
AA
n (%)
G
n (%)
A
n (%)
Patients with bruxism (AB)
n = 104
47 (45.1%) 55 (52.9%) 2 (2.0%) 146 (71.6%) 58 (28.4%)
Males (n = 26) 16 (61.5%) 9 (34.6%) 1 (3.9%) 41 (78.9%) 11 (21.1%)
Females (n = 78) 31 (39.7%) 46 (59.0%) 1 (1.3%) 108 (69.2%) 48 (30.8%)
Control group (C)
(n = 193)
116 (60.2%) 67 (34.7%) 10 (5.1%) 299 (77.5%)
*1000Genomes: 80.0%
87 (22.5%)
*1000Genomes: 20.0%
Control males
(n = 97)
63 (65.0%) 29 (29.9%) 5 (5.1%) 155 (79.9%) 39 (20.1%)
Control females
(n = 96)
53 (55.2%) 38 (39.6%) 5 (5.2%) 144 (75.0%) 48 (25.0%)
Comparisons of allelic and genotypic frequencies between groups under the study
  [GG + GA]vs[AA] [GG]vs[GA + AA] [GG]vs[AA] [G]vs[A] [A]vs[G]
AB** versus C
OR, 95% CI
P value
OR = 0.36
[0.08–1.67]
P = 0.174
OR = 0.55
[0.34–0.89]
P = 0.014
OR = 2.03
[0.43–9.60]
P = 0.365
OR = 0.735
[0.50–1.08]
P = 0.116
OR = 1.36
[0.93–2.00]
P = 0.116
AB males versus C males
OR, 95% CI
P value
OR = 0.74
[0.08–6.59]
P = 0.783
OR = 0.86
[0.35–2.11]
P = 0.747
OR = 1.27
[0.14–11.65]
P = 0.832
OR = 0.94
[0.44–1.99]
P = 0.867
OR = 1.07
[0.50–2.26]
P = 0.867
AB females** versus C females OR, 95% CI
P value
OR = 0.27
[0.03–2.07]
P = 0.158
OR = 0.54
[0.29–0.98]
P = 0.042
OR = 2.93
[0.33–26.19]
P = 0.317
OR = 0.75
[0.47–1.20]
P = 0.231
OR = 1.33
[0.83–2.14]
P = 0.231
AB females** versus AB males
OR, 95% CI
P value
OR = 0.33
[0.02–5.38]
P = 0.410
OR = 0.41
[0.17–1.03]
P = 0.053
OR = 1.93
[0.11–33.05]
P = 0.642
OR = 0.60
[0.29–1.28]
P = 0.183
OR = 1.66
[0.79–3.50]
P = 0.183
C females versus C males
OR, 95% CI
P value
OR = 1.01
[0.28–3.61]
P = 0.987
OR = 0.67
[0.37–1.19]
P = 0.167
OR = 0.84
[0.23–3.06]
P = 0.793
OR = 0.76
[0.47–1.22]
P = 0.250
OR = 1.33
[0.82–2.14]
P = 0.250
  1. In bold were marked statistically significant and borderline significant results (P < 0.05). No corrections for the multiple statistical testing were made
  2. [GG + GA] versus [AA] – dominant model, risk allele: G; [GG] versus [GA + AA] – recessive model, risk allele: A
  3. *Allele frequencies for the European population according to the 1000Genomes Project have been gathered from http://grch37.ensembl.org/Homo_sapiens/Variation/Population?r=11:27679416-27680416;v=rs6265;vdb=variation;vf=6008 website
  4. **HWE analysis revealed discordance in females with AB and a whole group of patients with AB