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Table 1 A summary of the patient's information organized as a timeline

From: Congenital anomalies-associated Riga–Fede disease as an early manifestation of Lesch–Nyhan syndrome: rare entities in the same pediatric patient—a case report

The event

Timeline

First clinical presentation (reported by parents)

January 2019

First medical consultation

March 17, 2019

Referral to the oral medicine clinic, diagnosis of RFD and the start of a primary treatment plan (topical analgesic, antifungal and supportive measures)

March 21, 2019

Grinding of deciduous teeth

March 25, 2019

Complete healing of ulcers and full restoration of proper breastfeeding

April 18, 2019

The appearance of neurological manifestations and self mutilating actions

January 2020

Premature loss of primary anterior teeth

From August to October 2020

The appearance of an eye ulcer from self mutilation

November 2020

Misdiagnosis of LNS

From January 2020 to January 2021

Lab investigations (kidney function tests and abdominal ultrasound) and the diagnosis of LNS

January 8 and 13, 2021

Presentation to the oral medicine clinic with a nasal ulcer and facial tissue deformity

January 28, 2021

Treatment plan for LNS

February 4, 2021

Follow-up reporting improvement of self mutilation and neurological manifestations

August 16, 2021