Table 2 ACE polymorphisms allele and genotype frequencies in patients with RAS and controls
ACE | Genotypes | Controls | RAS | P value | OR (CI 95%) | Controls | RAS | P value | OR (CI 95%) | Controls | RAS | P value | OR (CI 95%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alleles | N = 143 (%) | N = 87 (%) | Men | Men | Women | Women | |||||||
N = 65 (%) | N = 34 (%) | N = 78 (%) | N = 53 (%) | ||||||||||
rs4291 | AA | 59 (41.3) | 33 (37.9) | 1.00 | 30 (46.2) | 18 (52.9) | 1.00 | 29 (37.2) | 15 (28.3) | 1.00 | |||
AT | 70 (48.9) | 40 (46.0) | 0.365 | 0.98 (0.55–1.74) | 31 (47.7) | 12 (35.3) | 0.392 | 0.65 (0.27–1.57) | 39 (50.0) | 28 (52.8) | 0.462 | 1.39 (0.63–3.06) | |
TT | 14 (9.8) | 14 (16.1) | 1.79 (0.76–4.20) | 4 (6.1) | 4 (11.8) | 1.67 (0.37–7.50) | 10 (12.8) | 10 (18.9) | 1.93 (0.66–5.67) | ||||
A | 188 (65.7) | 106 (60.9) | 0.173 | 1.00 | 91 (70.0) | 48 (70.6) | 0.534 | 1.00 | 97 (62.2) | 58 (54.7) | 0.141 | 1.00 | |
T | 98 (34.3) | 68 (39.1) | 1.23 (0.83–1.82) | 39 (30.0) | 20 (29.4) | 0.97 (0.51–1.85) | 59 (37.8) | 48 (45.3) | 1.36 (0.82–2.25) | ||||
rs4305 | AA | 25 (17.5) | 17 (19.5) | 1.33 (0.60–2.95) | 11 (16.9) | 6 (17.6) | 1.13 (0.34–3.81) | 14 (17.9) | 11 (20.8) | 1.89 (0.64–5.56) | |||
AG | 73 (51.0) | 47 (54.0) | 0.712 | 1.26 (0.68–2.35) | 33 (50.8) | 15 (44.1) | 0.803 | 0.73 (0.39–1.85) | 40 (51.3) | 32 (60.4) | 0.312 | 1.92 (0.80–4.59) | |
GG | 45 (31.5) | 23 (26.5) | 1.00 | 21 (32.3) | 13 (38.3) | 1.00 | 24 (30.8) | 10 (18.8) | 1.00 | ||||
A | 123 (43.0) | 81 (46.6) | 0.259 | 1.15 (0.79–1.69) | 55 (42.3) | 27 (39.7) | 0.421 | 0.90 (0.49–1.63) | 68 (43.6) | 54 (50.9) | 0.034* | 1.66 (1.00–2.78) | |
G | 163 (57.0) | 93 (53.4) | 1.00 | 75 (57.7) | 41 (60.3) | 1.00 | 88 (56.4) | 42 (39.6) | 1.00 | ||||
rs4311 | CC | 41 (28.7) | 21 (24.1) | 1.00 | 20 (30.8) | 10 (29.4) | 1.00 | 21 (26.9) | 11 (20.8) | 1.00 | |||
CT | 77 (53.8) | 45 (51.8) | 0.437 | 0.88 (0.46–1.67) | 36 (55.4) | 17 (50.0) | 0.683 | 0.94 (0.36–2.45) | 41 (52.6) | 28 (52.8) | 0.615 | 1.30 (0.54–3.12) | |
TT | 25 (17.5) | 21 (24.1) | 1.64 (0.75–3.59) | 9 (13.8) | 7 (20.6) | 1.56 (0.45–5.41) | 16 (20.5) | 14 (26.4) | 1.67 (0.60–4.65) | ||||
C | 159 (55.6) | 87 (50.0) | 0.142 | 1.00 | 76 (58.5) | 37 (54.4) | 0.346 | 1.00 | 83 (53.2) | 50 (47.2) | 0.202 | 1.00 | |
T | 127 (44.4) | 87 (50.0) | 1.25 (0.86–1.83) | 54 (41.5) | 31 (45.6) | 1.18 (0.65–2.13) | 73 (46.8) | 56 (52.8) | 1.27 (0.78–2.09) | ||||
rs4331 | AA | 38 (26.6) | 23 (26.4) | 1.00 | 17 (26.2) | 6 (17.6) | 1.00 | 21 (26.9) | 17 (32.1) | 1.00 | |||
AG | 74 (51.7) | 48 (55.2) | 0.816 | 1.07 (0.57–2.02) | 32 (49.2) | 17 (50.0) | 0.552 | 1.51 (0.50–4.53) | 42 (53.9) | 31 (58.5) | 0.302 | 1.10 (0.50–2.42) | |
GG | 31 (21.7) | 16 (18.4) | 0.85 (0.39–1.89) | 16 (24.6) | 11 (32.4) | 1.95 (0.58–6.51) | 15 (19.2) | 5 (9.4) | 0.41 (0.12–1.36) | ||||
A | 150 (52.4) | 94 (54.0) | 0.408 | 1.00 | 66 (50.8) | 29 (42.6) | 0.175 | 1.00 | 84 (53.8) | 65 (61.3) | 0.142 | 1.00 | |
G | 136 (47.6) | 80 (46.0) | 0.94 (0.64–1.37) | 64 (49.2) | 39 (57.4) | 1.39 (0.77–2.50) | 72 (46.2) | 41 (38.7) | 0.74 (0.45–1.22) | ||||
rs1799752 (I/D) | II | 31 (21.7) | 11 (12.6) | 0.48 (0.21–1.12) | 15 (23.1) | 7 (20.6) | 0.66 (0.21–2.11) | 16 (20.5) | 4 (7.5) | 0.33 (0.09–1.17) | |||
ID | 74 (51.7) | 48 (55.2) | 0.209 | 1.14 (0.62–2.09) | 33 (50.8) | 15 (44.1) | 0.637 | 0.64 (0.25–1.68) | 41 (52.6) | 33 (62.3) | 0.127 | 1.06 (0.48–2.34) | |
DD | 38 (26.6) | 28 (32.2) | 1.00 | 17 (26.1) | 12 (35.3) | 1.00 | 21 (26.9) | 16 (30.2) | 1.00 | ||||
I allele | 136 (47.6) | 70 (40.2) | 0.075 | 0.74 (0.51–1.09) | 63 (48.5) | 29 (42.6) | 0.265 | 0.79 (0.44–1.43) | 73 (46.8) | 41 (38.7) | 0.120 | 0.72 (0.43–1.18) | |
D allele | 150 (52.4) | 104 (59.8) | 1.00 | 67 (51.5) | 39 (57.4) | 1.00 | 83 (53.2) | 65 (61.3) | 1.00 |