Fig. 2From: Influence of probiotics on the periodontium, the oral microbiota and the immune response during orthodontic treatment in adolescent and adult patients (ProMB Trial): study protocol for a prospective, double-blind, controlled, randomized clinical trialA time line showing all five study time points is given. Base line (T0) = before the insertion of the fixed appliance; T1 =  ~ one week (w) after insertion of fixed appliance/ start of lozenge intake; T2 =  ~ four w after insertion of fixed appliance/ start of lozenge intake; T3 =  ~ 12w after insertion of the fixed appliance = last day of lozenge intake; T4 =  ~ 24w after insertion of fixed appliance = 24w after start of lozenge intake = 12w after end of lozenge intakeBack to article page