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Fig. 2 | BMC Oral Health

Fig. 2

From: Influence of probiotics on the periodontium, the oral microbiota and the immune response during orthodontic treatment in adolescent and adult patients (ProMB Trial): study protocol for a prospective, double-blind, controlled, randomized clinical trial

Fig. 2

A time line showing all five study time points is given. Base line (T0) = before the insertion of the fixed appliance; T1 =  ~ one week (w) after insertion of fixed appliance/ start of lozenge intake; T2 =  ~ four w after insertion of fixed appliance/ start of lozenge intake; T3 =  ~ 12w after insertion of the fixed appliance = last day of lozenge intake; T4 =  ~ 24w after insertion of fixed appliance = 24w after start of lozenge intake = 12w after end of lozenge intake

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