Changes in salivary matrix metalloproteinase-3, -8, and -9 concentrations after 6 weeks of non-surgical periodontal therapy

Table 3 Changes in concentration of salivary MMPs over 6 weeks

Parameter	Periodontal status	Baseline	Week 3	Baseline to week 3		Week 6	Baseline to week 6
Parameter	Periodontal status	Baseline	Week 3	Difference	p-value*	Week 6	Difference	p-value*
MMP-3 (Ln pg/ml)	Periodontitis	5.68 ± 0.73	5.31 ± 0.92	0.41 ± 0.09	0.001	5.34 ± 0.86	0.38 ± 0.17	0.893
	Health subjects	4.98 ± 0.02	4.96 ± 0.15	0.02 ± 0.15	0.88	4.98 ± 0.19	0.00 ± 0.21	0.893
	p-value^†	0.001	0.099			0.806
MMP-8 (Ln pg/ml)	Periodontitis	7.98 ± 2.27	7.14 ± 2.44	0.47 ± 1.38	0.001	7.77 ± 2.48	0.81 ± 1.13	0.880
	Health subjects	7.05 ± 2.52	7.39 ± 2.26	0.56 ± 0.50	0.010	6.97 ± 1.58	0.68 ± 0.70	0.263
	p-value^†	0.041	0.089			0.010
MMP-9 (Ln pg/ml)	Periodontitis	9.30 ± 2.38	9.21 ± 2.26	0.43 ± 1.30	0.044	9.03 ± 2.20	0.71 ± 1.09	0.900
	Health subjects	8.50 ± 2.40	8.83 ± 2.34	0.68 ± 0.69	0.187	8.01 ± 1.45	0.80 ± 0.97	0.099
	p-value^†	< 0.001	0.620			< 0.001

MMP (Ln pg/ml) means ± SE and p-values were adjusted for age (continuous) and smoking
PD, periodontal pocket depth; CAL, clinical attachment level
Bold denotes statistical significance at p < 0.05
*Denotes statistically difference between periodontitis and healthy subjects by paired t-test
^†Calculated with the Wilcoxon test

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