Fig. 2
From: A new scoring system facilitating diagnosis of oral squamous malignancy on biopsy specimens
The expression patterns of biomarkers in non-tumor epithelia. a The histological picture of a nearly normal buccal mucosa (HE), showing a homogenous CK13 expression from the suprabasal layer (CK13 pattern A), absent CK17 expression (CK17 pattern B). The ki-67-labeled epithelial cells are confined to the suprabasal layers (Ki-67 pattern A). Ln5γ2 is barely detected at the junction between the epithelium and underlying connective tissue (Ln5γ2 pattern A1, arrow). b In an acanthotic epithelium (HE stain), decreased expression of CK13 is noted (CK13 pattern B), while expression of CK17 is increased (CK17 pattern B). The ki-67 positivity remains predominantly in the suprabasal layers (Ki-67 pattern A, magnified in the lower middle figure). A clear, uninterrupted staining of Ln5γ2 in the basement membrane is noted (Ln5γ2 pattern A2, arrows). HE, hematoxylin–eosin stain