Table 1 Expression patterns of CK13, CK17, Ki-67 and Ln5γ2 in oral verrucous carcinoma (OVC) vs squamous cell carcinoma (OSCC)
From: A new scoring system facilitating diagnosis of oral squamous malignancy on biopsy specimens
Marker | Representative expression pattern | OVC (n = 33) | OSCC (n = 21) | p value | Pattern score | |||
|---|---|---|---|---|---|---|---|---|
n | (%) | n | (%) | |||||
CK13 | A | Strong expression from 1st parabasal (2nd basal) layer | 0 | (0) | 0 | (0) | 0 | |
B | Decreased expression (other than pattern A or pattern C) | 13 | (39) | 12 | (57) | 0.20 | 1 | |
C | Very weak of total loss of CK13 expression | 20 | (61) | 9 | (43) | 2 | ||
CK17 | A | Very weak or no expression of CK17 | 3 | (9) | 0 | (0) | 0 | |
B | Increased expression (other than pattern A or pattern C) | 4 | (12) | 8 | (38) | 0.18a | 1 | |
C | Strong expression at tumor-stromal interface or whole epithelial layers | 26 | (79) | 13 | (62) | 2 | ||
Ki-67 | A | 1st parabasal layer ± scattered basal layer expression | 0 | (0) | 0 | (0) | 0 | |
B | Predominant basal layer expression (peripheral expression) | 11 | (33) | 15 | (71) | 0.06b | 3 | |
C | Diffuse expression both in basal and parabasal layers | 22 | (67) | 6 | (29) | 3 | ||
Ln5γ2 | A | No expression (A1) or on intact basement membrane only (A2) | 1 | (3) | 0 | (0) | 0 | |
B | Focal cytoplasmic staining cells at tumor-stroma interface (< 10%) | 15 | (45) | 2 | (10) | 4 | ||
C | Limited cytoplasmic staining cells at tumor-stroma interface (10–50%) | 12 | (36) | 7 | (33) | 4 | ||
D | Diffuse cytoplasmic staining cells at tumor-stroma interface (> 50%) | 5 | (15) | 12 | (57) | 0.0012c | 4 | |