Fig. 2

Histopathological features of the subtypes of NIGDUL: A “Bubbly” granulomatous reaction in the case of NIGDUL associated with silicone (H&E × 20), B Granulomatous reaction and crystalloid foreign body in the patient with NIGDUL associated with calcic hydroxyapatite (H&E × 20), C Round granuloma in the lamina propia of NIGDUL associated with Crohn’s disease, showing epithelioid, lymphoid and multinucleated giant cells (H&E × 20), D Granulomatous affectation of the salivary gland parenchyma in the same patient (H&E × 20), E Multiple granulomas and chronic mucositis (lichenoid-like) in a case of NIGDUL associated with gingivitis lichenoid-like (H&E × 10), F Detail of the chronic lymphocytic infiltration in the lamina propia with epithelial atrophy and degeneration of the basal cells (H&E × 20), G Small granuloma in the submucosa in a patient with NIGDUL NOS (H&E × 15), H Detail of this granuloma with histocytes and lymphocytes (H&E × 40)