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Table 3 Univariate and multivariate analyses of prognostic factors in 365 patients with OSCC

From: Prognostic role of an inflammation scoring system in radical resection of oral squamous cell carcinoma

Variable Univariate survival analysis Multivariate survival analysis
Hazard ratio 95% CI P-value Hazard ratio 95% CI P-value
Sex 1.054 0.662–1.679 0.823    
Currently smoking 0.931 0.426–2.031 0.857    
Currently drinking 0.869 0.350–2.157 0.761    
Age 1.858 1.036–3.333 0.038 1.930 1.051–3.546 0.034
Tumor size 3.355 2.024–5.555  < 0.001 2.469 1.408–4.329 0.002
Cervical nodal metastasis
 N0 Ref    Ref   
 N1 4.807 2.739–8.403  < 0.0001 2.688 1.373–5.263 0.004
 N2 2.941 1.344–6.410 0.007 3.663 0.686–3.787 0.273
Cancer subsites
 Lip Ref      
 Gingval 0.788 0.267–2.320 0.665    
 Buccal 1.194 0.646–2.206 0.572    
 Mouth floor 1.252 0.686–2.287 0.464    
 Tongue 0.765 0.178–3.286 0.719    
NLR 2.618 1.640–4.180  < 0.001 1.978 1.194–3.274 0.008
Fibrinogen (mg/dL) 8.128 3.641–18.144  < 0.001 5.301 2.426–11.581  < 0.001
MPV 2.707 1.577–4.645  < 0.001 1.804 1.041–3.127 0.035
PLR
 < 150 Ref    Ref   
 ≥ 150 ≤ 300 6.774 2.913–15.750  < 0.001 2.468 1.053–5.783 0.037
 > 300 6.758 3.406–13.406  < 0.001 2.388 1.152–4.951 0.019
F-NLR
 0 Ref    Ref   
 1 19.989 6.847–58.359  < 0.001 26.566 5.589–126.258  < 0.001
 2 2.621 1.612–4.261  < 0.001 3.895 1.321–11.485 0.014
LVI 2.290 1.401–3.744 0.001 2.079 1.234–3.496 0.006
PNI 2.390 0.750–7.616 0.141    
  1. Statistically significant values are shown in bold
  2. F-NLR the combined fibrinogen and NLR score, NLR Neutrophil-to-lymphocyte ratio, MPV mean platelet volume, PNI perineural invasion, LVI lymphatic and vascular invasion, OSCC oral squamous cell carcinoma