Effect of Enterococcus faecalis OG1RF on human calvarial osteoblast apoptosis

BMC Oral Health

Table 2 Apoptosis-related genes in E. faecalis-infected osteoblasts compared to the control sample

Rank	Gene	Accession number	Description	Fold change
Upregulated
1	TNF	NM_000594	Tumour necrosis factor	239.50**
2	TNFRSF9	NM_001561	Tumour necrosis factor receptor superfamily, member 9	30.73*
3	LTA	NM_000595	Lymphotoxin alpha (TNF superfamily, member 1)	29.13**
4	CD70	NM_001252	CD70 molecule	24.76**
5	BCL2A1	NM_004049	BCL2-related protein A1	14.92**
6	CASP10	NM_001230	Caspase 10, apoptosis-related cysteine peptidase	11.04**
7	TNFRSF10	NM_003810	Tumour necrosis factor (ligand) superfamily, member 10	10.52*
8	TNFRSF8	NM_001244	Tumour necrosis factor (ligand) superfamily, member 8	10.19**
9	BCL2L11	NM_006538	BCL2-like 11	6.78**
10	CASP3	NM_004346	Caspase 3, apoptosis-related cysteine peptidase	3.40**
11	HRK	NM_003806	Harakiri, BCL2-interacting protein	2.64*
12	CASP9	NM_001229	Caspase 9, apoptosis-related cysteine peptidase	2.61**
13	CASP8	NM_001228	Caspase 8, apoptosis-related cysteine peptidase	2.57**
14	TNFRSF1B	NM_001066	Tumour necrosis factor receptor superfamily, member 1B	2.41**
15	BIK	NM_001197	BCL2-interacting killer	2.20**
16	APAF1	NM_001160	Apoptotic peptidase activating factor 1	2.21**
Downregulated
1	BCL2	NM_000633	B-cell CLL/lymphoma 2	0.42*
2	NAIP	NM_004536	NLR family, apoptosis inhibitory protein	0.41**
3	BIRC6	NM_016252	Baculoviral IAP repeat containing 6	0.36**
4	XIAP	NM_001167	X-linked inhibitor of apoptosis	0.30**

Primary osteoblasts were incubated with E. faecalis OG1RF at an MOI of 1,000 for 12 h. Apoptosis-related genes (fold change > 2, P < 0.05). *P < 0.05 and **P < 0.01 versus the control group

ISSN: 1472-6831