Table 2 Selected study individual results

Abtahi et al. [26]

32 dental implants on 16 patients

1. Zolendronate coated dental implant

0.17 mm of marginal bone loss between groups

P < 0.006

2. Uncoated dental implant

No implant stability differences

Abtahi et al. [27]

32 dental implants on 16 patients

1. Zolendronate coated dental implant

Marginal bone loss difference between groups at 18 month was 0.50 mm

P = 0.04

2. Uncoated dental implant

Marginal bone loss difference between groups at 5 years was 0.34 mm

P = 0.04

Tallarico et al. [28]

98 dental implants in 32 patients

1. Dental implants in 6 month alendronated administration stopping patients

Dental implant success 98%; Prostheses success 98%; Survival rate 100%; Median marginal bone loss 1.35 mm; No differences between 1, 2 and 3 years of follow up on marginal bone loss Soft peri-implant tissue with positive parameters;

Differences on 1, 2 o 3 years of follow up P = 0.059

Zuffetti et al. [29]

155 dental impla ts in 39 patients

1. Standard dental implant procedure

Dental implant survival was 100% in test group and 91.3% in control group

P = 0.001

2. Standard dental implant procedure + a 3% chlodronate and surfactant solution rinse both at the implant surface and implant site

Marginal bone loss of 0.85 mm in test group and 1.12 mm in control group after one year

P = 0.15

Marginal bone loss of 0.98 mm in test group and 1.26 mm in control group after 5 years

P = 0.15

Mozzati et al. [8]

1267 dental implants on 235 patients

1. Oral bisphosphonate administred patients

Dental implant failure rate of 6.8%

–

López-Cedrún et al. [32]

57 dental implants on 9 patients

1. Oral bisphosphonate administred patients

–

–

Griffiths [33]

10 patients

1. Standard dental implant procedure

Bone mineral density (BMD) evaluation was lower in oral bisphosphonate patients

–

2. Standard dental implant procedure with 70 mg tablet or placebo of alendronate weekly for 6 months

Abtahi et al. [34]

32 dental implants on 16 patients

1. Pamidronate and ibandronate coated dental implant

Dental implant success rate of 100%; Larger implant stability quotient (ISQ) for bisphosphonate coated dental implant at 6 months

100%

2. Uncoated dental implant

Bone marginal loss was higher in non-coated dental implants at 6 months

P = 0.0001; P = 0.003

Shabestari et al. [35]

46 dental implants in 21 patients

1. Dental implant surgery in patients that started oral bisphosphonate therapy after healing

Bleeding on Probing (BoP); Probing Depth (PD)

Not significant differences between groups in all outcomes (P < 0.05)

2. Dental implant surgery in patient who undergone oral bisphosphonate therapy

Mobility; Thread exposure (TE)