Table 4 Tallarico et al. [28] dental implant surgery prophylaxis in bisphosphonate patients

6 months before surgery

Suspension of the BPs before surgery and if possible after surgery Professional hygiene

7 days before and after surgery

Amoxicillin and clavulanic acid, 1 tablet every 12 h (2 g for day) Metronidazole 250 mg; 2 tablets every 8 h (1.5 g for day) Chlorhexidine gluconate 0.2% (oral rinse)

Day surgery

Oral rinse with chlorhexidine gluconate 0.2% for 1 min Flapless or mini-flap approach Copious irrigation during implants sites preparation Two-stage implants placement

Post-surgical

Ibuprofen 600 mg every 8 h for 2 days (later on if needed) Periodic (3–6 months) follow-up