Fig. 6
From: Role of PI3K in the bone resorption of apical periodontitis
Effects of LY294002 on the proliferation activity and related gene and protein expression of osteoclasts and osteoblasts. A The cell proliferation of osteoclasts treated with LY294002; B the cell proliferation of osteoblasts treated with LY294002; C statistical analysis of mRNA expression of Akt (P = 0.023), Acp5 (P = 0.019) and NFATc1 (P = 0.011) in osteoblasts treated with LY294002; D statistical analysis of mRNA expression of Akt (P = 0.019), BMP-2 (P = 0.012) and Runx2 (P = 0.003) in osteoblasts treated with LY294002. E The expression of PI3K, TRAP and NFATc1 proteins in osteoclasts treated with LY294002; F statistical analysis of p-Akt (P = 0.009), TRAP (P = 0.039) and NFATc1 (P = 0.032) proteins expressed in osteoclasts; G the expression of PI3K, BMP-2 and Runx2 proteins in osteoblasts treated with LY294002; H statistical analysis of p-Akt (P = 0.027), Runx2 (P = 0.031) andBMP-2 (P = 0.028) proteins expressed in osteoblasts. *P < 0.05 represents a significant difference between the control and experimental groups