Fig. 8

Knockdown of HMG20A enhanced cisplatin sensitivity, and inhibited DNA damage repair, proliferation and invasion of OSCC cells. A, cell viability of BHY and HSC3 cells transfected with si-HMG20A or si-NC at different cisplatin concentrations. B, IC₅₀ to cisplatin of BHY and HSC3 cells transfected with si-HMG20A or si-NC. C, BHY and HSC3 cells transfected with si-HMG20A or si-NC were treated with 5 µM cisplatin for 48 h. Western blotting was used to measure the protein levels of ERCC1 and γ-H2AX. β-actin was the internal control. D/E, BHY and HSC3 cells transfected with si-HMG20A or si-NC were treated with 5 µM cisplatin for 48 h. CCK8 and Transwell assay was used to detect cell proliferation (D) and invasion (E). **P < 0.01, si-HMG20A group vs. si-NC group