Fig. 2

Mutated profiling in TCGA and differential expression analysis. A Landscape of mutation profiles of top 20 genes. The waterfall plot shows the mutation information of each gene. B Distribution graph of TMB. The horizontal axis is TMB values and the vertical axis is TMB values of log base 10. C Volcano plot of DEGs. The horizontal axis is Log₂FC and the vertical axis is log₁₀ (adj. p. value). The blue dots are downregulation genes and the red dots are upregulation genes. D Heatmap of DEGs. The horizontal and vertical axes are samples and different genes respectively. The red represents high expression of genes and the blue represents low expression of genes. The green is upregulation genes and the purple is downregulation genes