Fig. 4
From: Upregulated Vanins and their potential contribution to periodontitis
VNN1 and VNN2 were at higher concentrations and got involved in the histopathological changes of gingival tissues with periodontitis. A HE staining and immunohistochemical staining of VNN1 and VNN2 in gingival tissues of periodontal healthy individuals and patients with periodontitis. Positive expression areas of VNN1 and VNN2 were brownish yellow in the connective tissue. B The positive area percentage of VNN1 and VNN2 in the gingiva from periodontal healthy individuals (n = 6) and patients with periodontitis (n = 12). C The quantitative analysis of AOD of VNN1 and VNN2 in the gingiva from healthy (n = 6) and periodontitis (n = 12) subjects. Significance was defined in the figure as * p < 0.05, ** p < 0.01, and *** p < 0.001. AOD, average optical density