Table 2 Eligible studies for OM prevention
First author (year) | Population | Intervention | Experimental arm 1 | Experimental arm 2 | Control arm | Outcomes | Study design | OM assessment grade | OM assessment performer | Results |
|---|---|---|---|---|---|---|---|---|---|---|
Piredda (2017) [17] | 60 patients under chemotherapy (30 in the experimental arm and 30 in the control arm) | prevention | dry extract of propolis with 8–12% of galangin plus mouth rinsing with SB | – | SB mouthwash | Clinical efficacy, safety, tolerability and compliance of propolis, incidence and severity of OM | RCT | Modified National Cancer Institute Scale version 4.0 | Unknown plus telephone assessment | Propolis plus SB was more effective than SB alone in preventing OM graded higher than G1. |
Chitapanarux (2018) [18] | 60 patients under chemo + radiotherapy (30 in the experimental arm and 30 in the control arm) | prevention | 0.15% benzydamine hydrochloride mouthwash | – | SB mouthwash | Effectiveness of the mouthwash, pain score | RCT | The Oral Mucositis Assessment Scale (OMAS) | Oncologists | The median of OMAS scores at every weekly assessment was lower in the benzydamine HCl group compared to that of the control group. |
De Sanctis (2019) [19] | 68 patients under chemo + radiotherapy (32 in the experimental arm and 36 in the control arm) | prevention | Lactobacillus brevis CD2 lozenges | – | SB mouthwash | Incidence of OM, pain, dysphagia, body weight loss and quality of life | RCT | NCI Common Toxicity Criteria scoring system version 4.0 | Trained physicians | No differences |
Alkhouli (2021) [20] | 22 patients under chemotherapy (11 in the experimental arm and 11 in the control arm) | prevention | 70% aloe-vera solution | – | SB 5% mouthwash | Efficacy of Aloe Vera, severity of mucositis | RCT | Who grading scale | unknown | Topical use of aloe-vera was efficient in the prevention of OM compared to SB 5%. |