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Fig. 2 | BMC Oral Health

Fig. 2

From: Low-level laser therapy prevents medication-related osteonecrosis of the jaw-like lesions via IL-1RA-mediated primary gingival wound healing

Fig. 2

LLLT inhibited pro-inflammation cytokines, increased IL-1RA expression, and suppressed tissue inflammation in the gingiva. A–C Target gene mRNA expression levels in the gingival tissue of each group. D ELISA results of IL-1β levels in gingival tissue in each group. E Images of IL-1β and TNF-α IHC staining of the mouse gingival wound. Scale bar = 100 μm. F Images of IL-1β and TNF-α IHC staining of the human gingival wound. Scale bar = 100 μm. G Images of IL-1RA IF staining of the mouse gingival wound. White dotted lines represent the dividing line between the epithelium and the connective tissue. Scale bar = 50 μm. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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BMC Oral Health

ISSN: 1472-6831

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