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Fig. 3 | BMC Oral Health

Fig. 3

From: Low-level laser therapy prevents medication-related osteonecrosis of the jaw-like lesions via IL-1RA-mediated primary gingival wound healing

Fig. 3

Application of IL-1RA NAb impairs the capacity of LLLT to promote gingival wound healing. A The study's experimental protocols are depicted in this diagram. B Representative intraoral photos. (Ctrl: non-drug treatment, but treated with negative control antibodies group; Zol: treated with Zol and negative control antibodies group; Zol + LLLT: treated with Zol, LLLT, and negative control antibodies group; Zol + LLLT + IL-1RA: treated with Zol, LLLT, and IL-1RA NAb group). Green dotted lines represent unhealed gingiva. C MicroCT reconstructed 3D images of tooth sockets. Green dotted lines represent tooth sockets. D, E Quantification of BMD and BV/TV in each group. F H&E staining shows tooth extraction sockets-wound healing in each group. Black dotted boxes represent magnified boxed regions. Green dotted lines represent unhealed gingiva. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). G, H Images of IL-1β and TNF-α IHC staining of the mouse gingival wound. Scale bar = 100 μm. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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BMC Oral Health

ISSN: 1472-6831

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