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Fig. 5 | BMC Oral Health

Fig. 5

From: Low-level laser therapy prevents medication-related osteonecrosis of the jaw-like lesions via IL-1RA-mediated primary gingival wound healing

Fig. 5

The schematic hypothesis of the function of LLLT to promote wound healing. Our results suggest that LLLT decreases IL-β and IL-6, and increases IL-1RA at the gingival wound, promoting wound healing and bone regeneration. The IL-1 signaling pathway is initiated when IL-1α or IL-1β binds to the members of the IL-1R1 family, which recruits MyD88, IRAK, and TRAF6 to activate NF-κB and MAPK and then controls the transcription of several inflammatory genes. IL-1RA can suppress this interaction competitively

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BMC Oral Health

ISSN: 1472-6831

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