Table 3 Top 10 enriched pathways in the Co-DEmiRNA-gene network
From: Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma
KEGG pathway | Value |
|---|---|
Focal adhesion | 5.34e−05 |
ECM-receptor interaction | 0.000264 |
Pathways in cancer | 0.00109 |
Melanoma | 0.00121 |
Small cell lung cancer | 0.00222 |
Glioma | 0.0104 |
p53 signaling pathway | 0.0117 |
mRNA surveillance pathway | 0.0194 |
TGF-beta signaling pathway | 0.0207 |
Asthma | 0.0484 |
Reactome pathway | |
 Signaling by SCF-KIT | 1.43E−05 |
 Oncogene Induced Senescence | 1.70E−05 |
 Pre-NOTCH Transcription and Translation | 4.81E−05 |
 PI3K events in ERBB4 signaling | 7.45E−05 |
 PIP3 activates AKT signaling | 7.45E−05 |
 PI3K events in ERBB2 signaling | 7.45E−05 |
 PI-3K cascade:FGFR1 | 7.45E−05 |
 PI-3K cascade: FGFR2 | 7.45E−05 |
 PI-3K cascade:FGFR3 | 7.45E−05 |
 PI-3K cascade:FGFR4 | 7.45E−05 |
GO-BP | |
 Negative regulation of cellular process | 1.76e−05 |
 Ras protein signal transduction | 1.78e−05 |
 Neurogenesis | 3.82e−05 |
 Generation of neurons | 6.59e−05 |
 Response to external stimulus | 0.000108 |
 Skeletal system development | 0.000116 |
 Neuron projection development | 0.000123 |
 Nervous system development | 0.000136 |
 Regulation of cell proliferation | 0.000193 |
 Negative regulation of biological process | 0.000207 |
GO-MF | |
 Growth factor binding | 1.03e−05 |
 Extracellular matrix structural constituent | 1.65e−05 |
 Transcription from RNA polymerase II promoter | 0.000364 |
 Nucleotide binding | 0.00263 |
 Protein phosphatase type 2A regulator activity | 0.00346 |
 Negative regulation of transcription DNA-dependent | 0.0054 |
 Purine ribonucleotide binding | 0.00642 |
 Purine nucleotide binding | 0.00661 |
 Protein serine/threonine kinase activity | 0.00759 |
 Protein serine/threonine/tyrosine kinase activity | 0.0101 |
GO-CC | |
 Growth factor binding | 1.03e−05 |
 Extracellular matrix structural constituent | 1.65e−05 |
 Transcription from RNA polymerase II promoter | 0.000364 |
 Nucleotide binding | 0.00263 |
 Protein phosphatase type 2A regulator activity | 0.00346 |
 Negative regulation of transcription, DNA-dependent | 0.0054 |
 Purine ribonucleotide binding | 0.00642 |
 Purine nucleotide binding | 0.00661 |
 Protein serine/threonine kinase activity | 0.00759 |
 Protein serine/threonine/tyrosine kinase activity | 0.0101 |