Fig. 2
Apical periodontitis establishment and status after treatment with MK-886. A Photomicrographs of healthy teeth, obtained after LPS inoculation into root canals, or at time intervals of 7 and 14 days after treatment with and without MK-886. HE, original 20× magnification (scale bar = 100 µm). B Graphic representation of the measurement of area of apical periodontitis, in µm2 in the different groups at 7 and 14 days (median and interquartile range). Dashed line indicates the area of a healthy periodontal ligament. * p < 0.05 compared with healthy periodontal ligament; # p < 0.05 compared with inoculation of LPS alone into the root canals; &p < 0.05 comparison between 7 and 14 days of the same treatment