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Table 2 Characteristics of the included studies exploring the removal of smear layer, debris and soft tissue

From: Cleaning efficacy of EDDY versus ultrasonically-activated irrigation in root canals: a systematic review and meta-analysis

Study (year)

Sample size per group

Sample types

Apical preparation size

Parameters of UAI tips

Power of ED

Placement of tips

Volume and concentration of activatied irrigants and activation time

Research indications

Obser-vational sites

Evaluation methods

Main results

Al-Rujaib et al. (2022) [63]

20

Single canals of lower premolars

40 / 06

25 / 00

30 kHz

6 kHz

WL-2 mm

10 ml 5.25%NaOCl

5 ml 17%EDTA

60 s × 3

Smear layer and debris

Coronal

Middle

Apical

SEM analysis

400 × magnifi-cation for debris

1000 × for smear layer

5-grade scoring system

Significant-ly less debris at apical thirds and less smear layer at all thirds in ED than UAI

Haupt et al. (2020) [49]

20

Curved (20°-40°) mesiobuccal canals of lower molars

40 / 04

15 / 02

30 kHz

5 kHz

WL-1 mm

6 ml 5%NaOCl

20 s × 3

Smear layer and debris

Coronal

Apical

SEM analysis

200 × magnifi-cation for debris

1000 × for smear layer

5-grade scoring system

No significant differences between UAI and ED

Plotino et al. (2021) [52]

10

Straight (< 10°) single round canals of single-rooted teeth

40 / 06

15 / 00

30 kHz

5 kHz

WL-1 mm

3 ml 5%NaOCl 20 s × 3

Exp 1: activated after instrumen-tation

Exp 2: activated during and after instrumentation

Smear layer and debris

Coronal

Middle

Apical

SEM analysis

1000 × magnifi-cation for smear layer and debris

4-grade scoring system

No significant differences between UAI and ED

Urban et al. (2017) [55]

12

Single round canals of lower premolars

40 / 06

15 / 00

30 kHz

6 kHz

WL-1 mm

3%NaOCl

30 s × 3

Smear layer and debris

Coronal

Middle

Apical

SEM analysis

200 × magnifi-cation for debris

1000 × for smear layer

5-grade scoring system

No significant differences between UAI and ED

Zhang et al. (2021) [45]

15

Straight (< 10°) single canals of lower premolars

40 / 06

25 / 02

NM

6 kHz

WL-2 mm

3 ml 17%EDTA

3 ml 3%NaOCl

30 s × 2

Smear layer

Coronal

Middle

Apical

SEM analysis

1000 × magnifi-cation for smear layer

5-grade scoring system

No significant differences between UAI and ED

Linden et al. (2020) [22]

9

Curved mesial canals connected by an isthmus of lower molars

30 / 07

20 / 00

45% of the maximum power (‘yellow 9’)

6 kHz

WL-2 mm

3 ml 2.5%NaOCl

20 s × 3

Debris

Canals and isthmus

Percentage of debris reduction evaluated by micro-CT

voxel size of 12 µm

Significant-ly more debris removed by UAI than ED

Rödig et al. (2019)[24]

10

Curved (10°-25°) Vertucci II mesial canals of lower molars

25 / 08

25 / 00

30 kHz

6 kHz

WL-2 mm

5 ml 1%NaOCl

2 ml 17%EDTA

20 s × 4

Debris

Canals and isthmus

Percentage of debris reduction evaluated by micro-CT

voxel size of 10.5 µm

No significant differences between UAI and ED

Rodrigues et al. (2021)[53]

8

Curved (20°-46°) Vertucci I mesial canals of lower molars

25 / 08

15 / 02

medium power

6 kHz

UAI: WL-2 mm

ED: WL-1 mm

10 ml 5%NaOCl

5 ml 17%EDTA

20 s × 3

Debris

Canals and isthmus

Percentage of debris reduction evaluated by micro-CT

voxel size of 12.8 µm

No significant differences between UAI and ED

Alsubait et al. (2021) [46]

14

Curved (10°-25°) mesial canals with isthmus of lower molars

30 / 09

20 / 00

power 8

6 kHz

WL-1 mm

2 ml NM NaOCl

30 s × 3

Debris

3 mm and 5 mm from the apex

Percentage of debris reduction evaluated by a stereomicroscope at 50 × magnifi-cation

No significant differences between UAI and ED

Al-Jadaa et al. (2023) [62]

9

Resin blocks with 2 canals connected by an isthmus containing artificial debris

45 / 05

25 / NM

38 kHz

6 kHz

2 mm from the apical foramen

1 ml 1.3%NaOCl

20 s × 3

Debtis

Isthmus

Cleared surface area in the isthmus recorded by a camera

No significant differences between UAI and ED

Plotino et al. (2019) [23]

Tests repeated 10 times per group

Canal resin models with 3 circular cavities

2.5 mm / 00a

Group 1:

15 / 02 40 kHz

Group 2:

15 / 02 28-36 kHz

Group 3:

15 / 00 28-36 kHz

6 kHz

WL-1 mm

Exp 1: NM 5%NaOCl 20 s × 3

Exp 2: NM 17%EDTA 20 s × 3

Debris

Coronal, middle and apical semi-circles

Percentage of debris reduction evaluated by a digital camera

Significant-ly more debris removed by ED than all UAI groups

Conde et al. (2017) [12]

10

Maxillary central incisors

30 / 06

20 / 00

power 4

NM

WL-2 mm

3 ml 2.5%NaOCl

1 ml 17%EDTA

30 s × 2

Soft tissue

Artificial grooves at WL-2 mm and WL-6 mm

Percentage of weight reduction of pigs' palatal mucosa in the grooves

No significant differences between UAI and ED

Iandolo et al. (2021) [51]

Tests repeated 20 times per group

An upper

single-rooted premolar with two root canals and an isthmus

25 / NM

15 / 02

40 kHz

6 kHz

WL-1 mm

Exp 1: 10 ml NM NaOCl 30 s × 10

Exp 2: 10 ml NM heated NaOCl 30 s × 10

Soft tissue

Isthmus

Area of pulp tissue after irrigation recorded by a digital camera and calculated in pixels

No significant differences between UAI and ED in exp 1 or exp 2

  1. UAI ultrasonically-activated irrigation, ED EDDY, WL Working length, SEM scanning electronic microscope, Exp experiment, NM not mentioned
  2. aThe resin model used in the study were 2.5 mm in width and had no taper